Ekaterina V. Kulchavenia
Abstract
Overactive bladder (OAB) is a very common condition. OAB undoubtedly requires correction since it significantly affects the patient’s quality of life. Literature review showed that pharmacokinetic and metabolic characteristics of trospium chloride make it a drug of choice in elderly and comorbid patients. There is a clear correlation between intestine and bladder dysfunction. The effects of rebamipide discovered by experiments, such as restoration of the damaged urothelium structure and function, as well as suppression of the overactive bladder, require further in-depth study and introduction of the drug to clinical practice for treatment of patients with chronic cystitis and OAB.
Key words: bladder, intestines, overactive bladder, capillary leak syndrome, trospium chloride, rebamipide.
About the Author
Ekaterina V. Kulchavenia 11 Novosibirsk Tuberculosis Research Institute, Novosibirsk, Russia; Novosibirsk State Medical University, Novosibirsk, Russia
References
1. Kazilov Yu.B., Gadzhieva Z.K. Rasprostranennost' razlichnykh narushenii mocheispuskaniia. Urologiia. 2016; 5: 109–14 (in Russian).
2. Kul'chavenia E.V., Kholtobin D.P., Shevchenko S.Iu. et al. Chastota khronicheskogo prostatita v strukture ambulatornogo urologicheskogo priema. Eksperimental'naia i klinicheskaia urologiia. 2015; 1:
16–9 (in Russian).
3. Harnett MD, Shipley J, MacLean L et al. Study of the population pharmacokinetic characteristics of once-daily trospium chloride 60 mg extended-release capsules in patients with overactive bladder and in healthy subjects. Clin Drug Investig 2013; 33 (2): 133–41. DOI: 10.1007/s40261-012-0039-8
4. Yu HJ, Liu CY, Lee KL et al. Overactive bladder syndrome among community-dwelling adults in Taiwan: prevalence, correlates, perception, and treatment seeking. Urol Int 2006; 77: 327–33. DOI: 10.1111/j.1464-410X.2009.08371.x
5. Hsu FC, Weeks CE, Selph SS et al. Updating the evidence on drugs to treat overactive bladder: a systematic review. Int Urogynecol J 2019; 30 (10): 1603–17. DOI: 10.1007/s00192-019-04022-8
6. Coyne KS, Margolis MK, Kopp ZS, Kaplan SA. Racial differences in the prevalence of overactive bladder in the United States from the epidemiology of LUTS (EpiLUTS) study. Urology 2012; 79 (1): 95–101. DOI: 10.1016/j.urology.2011.09.010
7. Luchinskii S.A. Farmakologicheskaia korrektsiia seksual'nykh disfunktsii u zhenshchin s giperaktivnym mochevym puzyrem. Avtoref. dis. ... kand. med. nauk. Tikhookean. gos. med. universitet. Vladivostok, 2015 (in Russian).
8. Coyne KS, Sexton CC, Irwin DE et al. The impact of overactive bladder, incontinence and other lower urinary tract symptoms on quality of life, work productivity, sexuality and emotional well-being in men and women: results from the EPIC study. BJU Int 2008; 101 (11): 1388–95. DOI: 10.1111/j.1464-410X.2008.07601.x
9. Coyne KS, Wein AJ, Tubaro A et al. The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. BJU Int 2009; 103 (Suppl. 3): 4–11.
10. Stewart WF, Van Rooyen JB, Cundiff GW et al. Prevalence and burden of overactive bladder in the United States. World J Urol 2003; 20 (6): 327–6. DOI: 10.1007/s00345-002-0301-4
11. Sexton CC, Coyne KS, Vats V et al. Impact of overactive bladder on work productivity in the United States: results from EpiLUTS. Am
J Manag Care 2009; 15 (Suppl. 4): S98–s107.
12. Chapple CR. Muscarinic receptor antagonists in the treatment of overactive bladder. Urology 2002; 55 (Suppl.): 33–46.
13. Hsiao SM, Chang TC, Chen CH et al. Frequent nocturia episodes, a suboptimal response to treatment, and small bladder capacity predict the need for persistent antimuscarinic therapy or re-treatment after discontinuation of antimuscarinics in female overactive bladder. Menopause 2017; 24: 100–4.
14. Hsiao SM, Liao SC, Chen CH et al. Psychometric assessment of female overactive bladder syndrome and antimuscarinics-related effects. Maturitas 2014; 79: 428–34.
15. Hsiao SM, Lin HH, Kuo HC. The role of serum C-reactive protein in women with lower urinary tract symptoms. Int Urogynecol J 2012; 23: 935–40.
16. Kuo HC, Lee KS, Na Y et al. Results of a randomized, double-blind, parallel-group, placebo and active-controlled, multicenter study of mirabegron, a β3-adrenoceptor agonist, in patients with overactive bladder in Asia. Neurourol Urodyn 2015; 34: 685–92.
17. Abrams P, Andersson KE, Buccafusco JJ et al. Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder. Br J Pharmacol 2006; 148 (5): 565–78. DOI: 10.1038/sj.bjp.0706780
18. Kumar V, Templeman L, Chapple CR, Chess-Williams R. Recent developments in the management of detrusor overactivity. Curr Opin Urol 2003; 13 (4): 285–91.
19. Manjunatha R, Pundarikaksha HP, Hanumantharaju BK, Anusha SJ. A prospective, comparative study of the occurrence and severity of constipation with darifenacin and trospium in overactive bladder.
J Clin Diagn Res 2015; 9 (3): FC05–9.
20. Biastre K, Burnakis T. Trospium chloride treatment of overactive bladder. Ann Pharmacother 2009; 43 (2): 283–95. DOI: 10.1345/aph.1L160
21. Kul'chavenia E.V. Novyi podkhod k ponimaniiu patogeneza i k lecheniiu infektsionno-vospalitel'nykh zabolevanii mochepolovoi sistemy. Urologiia. 2020; 5: 99–105. DOI: 10.18565/urology.2020.5.99-105 (in Russian).
22. Wolnicki M, Aleksandrovych V, Gil K. Interstitial cells of Cajal and telocytes in the urinary system: facts and distribution. Folia Med Cracov 2016; 56 (4): 81–9.
23. Faussone-Pellegrini MS, Cortesini C, Romagnoli P. Ultrastructure of the tunica muscularis of the cardial portion of the human esophagus and stomach, with special reference to the so-called Cajal’s interstitial cells. Arch Ital Anat Embriol 1977; 82: 157–77.
24. Huizinga JD, Zarate N, Farrugia G. Physiology, injury, and recovery of interstitial cells of Cajal: basic and clinical science. Gastroenterology 2009; 137: 1548–56.
25. Koh SD, Sanders KM, Ward SM. Spontaneous electrical rhythmicity in cultured interstitial cells of cajal from the murine small intestine.
J Physiol 1998; 513: 203–13.
26. Huizinga JD, Thuneberg L, Klüppel M et al. W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature 1995; 373: 347–9.
27. Farrugia G. Interstitial cells of Cajal in health and disease. Neurogastroenterol Motil 2008; 20 (Suppl/ 1): 54–63.
28. McCloskey K.D. Interstitial cells in the urinary bladder – localization and function. Neurourol Urodyn 2010; 29: 82–7.
29. Gil K, Urbanowicz W, Thor P. Localization and functions of c-kit positive cells in the urinary tract. Folia Med Cracov 2009; 50: 85–93.
30. Koleda P, Pilecki W. Nature of Interstitial Cells of Cajal of the Upper Urinary Tract. Advanc Clin Experiment Med 2014; 23 (4): 627–32.
31. Metzger R, Schuster T, Till H et al. Cajal-like cells in the upper urinary tract: comparative study in various species. Pediatr Surg Int 2005; 21 (3): 169–74.
32. Iatsina A.I., Vernigorodskii S.V., Kostev F.I. Morfologicheskii analiz interstitsial'nykh kletok kakhalia i bazofil'nykh granulotsitov pri giperaktivnom mochevom puzyre i stressovom nederzhanii mochi v eksperimente i pri farmakokorrektsii. Vestnik morfologii. 2018; 24 (2): 5–13 (in Russian).
33. Chuang FC, Liu HT, Wang LY, Kuo HC. Overactive bladder changes with time: a 5-year longitudinal follow up of changes in overactive bladder symptoms, urodynamic studies and urinary nerve growth factor levels. J Urol 2014; 192: 458–63.
34. Chung SD, Liu HT, Lin H, Kuo HC. Elevation of serum c-reactive protein in patients with OAB and IC/BPS implies chronic inflammation in the urinary bladder. Neurourol Urodyn 2011; 30: 417–20.
35. Kupelian V, Rosen RC, Roehrborn CG et al. Association of overactive bladder and C-reactive protein levels. Results from the Boston Area Community Health (BACH) survey. BJU Int 2012; 110: 401–7.
36. Kuo HC. Potential biomarkers utilized to define and manage overactive bladder syndrome. Low Urin Tract Symptoms 2012; 4 (Suppl. 1): 32–41.
37. Abreu GE, Dourado ER, Alves DN et al. Functional constipation and overactive bladder in women: a population-based study. Arq Gastroenterol 2018; 55 (Suppl. 1): 35–40. DOI: 10.1590/S0004-2803.201800000-46
38. Mugie SM, Koppen IJN, van den Berg MM et al. Brain processing of rectal sensation in adolescents with functional defecation disorders and healthy controls. Neurogastroenterol Motil 2018; 30:
e13228.
39. Mugie SM, Benninga MA, Di Lorenzo C. Epidemiology of constipation in children and adults: a systematic review. Best Pract Res Clin Gastroenterol 2011; 25: 3–18.
40. Wiley JW, Chang L. Functional Bowel Disorders. Gastroenterology 2018; 155 (1): 1–4. DOI: 10.1053/j.gastro.2018.02.014
41. Sampaio C, Sousa AS, Fraga LG et al. Constipation and lower urinary tract dysfunction in children and adolescents: a population-based study. Front Pediatr 2016; 4: 101.
42. Coyne KS, Cash B, Kopp Z et al. The prevalence of chronic constipation and faecal incontinence among men and women with symptoms of overactive bladder. BJU Int 2011; 107: 254–61.
43. Maeda T, Tomita M, Nakazawa A et al. Female functional constipation is associated with overactive bladder symptoms and urinary incontinence. Biomed Res Int 2017; 2017: 2138073.
44. Behzad E, Pirzadeh S, Mohseni M. Bowel habit reference values and abnormalities in young Iranian healthy adults. Dig Dis Sci 2007; 52: 1810–3.
45. Howell SC, Quine S, Talley NJ. Low social class is linked to upper gastrointestinal symptoms in an Australian sample of urban adults. Scand J Gastroenterol 2006; 41: 657–66.
46. Schmidt FM, Santos VL. Prevalence of constipation in the general adult population: an integrative review. Wound Ostomy Continence Nurs 2014; 41: 70–6.
47. Panayi DC, Khullar V, Digesu GA et al. Rectal distension: the effect on bladder function. Neurourol Urodyn 2011; 30: 344–7.
48. McMahon SB, Morrison JF. Two group of spinal interneurones that respond to stimulation of the abdominal viscera of the cat. J Physiol 1982; 322: 21–34.
49. Rouzade-Dominguez ML, Miselis R, Valentino RJ. Central representation of bladder and colon revealed by dual transsynaptic tracing in the rat: substrates for pelvic visceral coordination. Eur J Neurosci 2003; 18: 3311–24.
50. Ketai LH, Komesu YM, Dodd AB et al. Urgency urinary incontinence and the interoceptive network: a functional magnetic resonance imaging study. Am J Obstet Gynecol 2016; 215: 449.
51. Kato T, Honda Y, Kurita Y et al. Lubiprostone improves intestinal permeability in humans, a novel therapy for the leaky gut: A prospective randomized pilot study in healthy volunteers. PLoS One 2017; 12 (4): e0175626. DOI: 10.1371/journal.pone.0175626
52. Manfredo Vieira S, Hiltensperger M, Kumar V et al. Translocation of a gut pathobiont drives autoimmunity in mice and humans [published correction appears in Science 2018; 360 (6388)] Science 2018; 359 (6380): 1156–61. DOI: 10.1126/science.aar7201
53. Knoop KA, McDonald KG, Kulkarni DH, Newberry RD. Antibiotics promote inflammation through the translocation of native commensal colonic bacteria. Gut 2016; 65 (7): 1100–9. DOI: 10.1136/gutjnl-2014-309059
54. De-Souza DA, Greene LJ. Intestinal permeability and systemic infections in critically ill patients: effect of glutamine. Crit Care Med 2005; 33 (5): 1125–35. DOI: 10.1097/01.ccm.0000162680.52397.97
55. Terpstra ML, Singh R, Geerlings SE, Bemelman FJ. Measurement of the intestinal permeability in chronic kidney disease.World J Nephrol 2016; 5 (4): 378–88. DOI: 10.5527/wjn.v5.i4.378
56. Fry CH, Vahabi B. The Role of the Mucosa in Normal and Abnormal Bladder Function. Basic Clin Pharmacol Toxicol 2016; 119 (Suppl. 3): 57–62. DOI:10.1111/bcpt.12626
57. Kunst M.A., Yakupova S.P., Zinkevich O.D. et al. The role of microbial infection and intestinal permeability in the pathogenesis of rheumatoid arthritis. Practical medicine. 2014; 4 (80): 56–8 (in Russian).
58. Lee SJ. Recent advances in managing lower urinary tract infections. F1000Res 2018; 7: F1000 Faculty Rev-1964. DOI:10.12688/f1000research.16245.1
59. Tassopoulos A, Chalkias A, Papalois A et al. The effect of antioxidant supplementation on bacterial translocation after intestinal ischemia and reperfusion. Redox Rep 2017; 22 (1): 1–9. DOI: 10.1080/13510002.2016.1229893
60. Chin HJ, Oh YK, Jung YC et al. The phase II clinical study of rebamipide (mucosta tablet) on chronic glomerulonephritis patients. J Korean Society Clin Pharmacol Therapeut 1997; 5 (2), 170–82.
61. Sun M, Deng Z, Shi F et al. Rebamipide-loaded chitosan nanoparticles accelerate prostatic wound healing by inhibiting M1 macrophage-mediated inflammation via the NF-κB signaling pathway. Biomater Sci 2020; 8 (3): 912–25. DOI: 10.1039/c9bm01512d
62. Funahashi Y, Yoshida M, Yamamoto T et al. Intravesical application of rebamipide suppresses bladder inflammation in a rat cystitis model. J Urol 2014; 191 (4): 1147–52. DOI: 10.1016/j.juro.2013.11.026
63. Funahashi Y, Yoshida M, Yamamoto T et al. Intravesical application of rebamipide promotes urothelial healing in a rat cystitis model.
J Urol 2014; 192 (6): 1864–70. DOI: 10.1016/j.juro.2014.06.081
For citation:Kulchavenia E.V. Bladder and bowel: friends or enemies? Clinical review for general practice. 2020; 3: 39–44. DOI: 10.47407/kr2020.1.3.00022
All accepted articles publish licensed under a Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.