Clinical review for general practice

ISSN (Print) 2713-2552
ISSN (Online) 2782-5671
  • Home
  • about
  • archives
  • contacts
left
FULLSCREEN > Archive > 2021 > Statin-induced myopathy associated with atorvastatin therapy in the elderly patient. Clinical case

Statin-induced myopathy associated with atorvastatin therapy in the elderly patient. Clinical case

Natalia A. Cherkasova , Irina S. Komarova , Nadezhda V. Mukhina , Nikita V. Dyatlov

For citation:


  • Abstract
  • About the Author
  • References

Abstract

Statins are widely used in patients with cardiovascular disorders. However, the issue of the feasibility of prescribing the high-dose and medium-dose statins to elderly patients remains a matter of discussion. That is due to higher prevalence of the statin therapy side effects in this age group. The paper reports a clinical case of statin-induced myopathy, associated with the prolonged use of atorvastatin, in the elderly patient.
Key words: elderly patient, atorvastatin, statin-induced myopathy.

Портал CON-MED.RU:
https://con-med.ru/magazines/klinicheskiy_razbor_v_obshchey_meditsine/klinicheskiy_razbor_v_obshchey_meditsine-10-2021/statin_indutsirovannaya_miopatiya_na_fone_priema_atorvastatina_u_patsienta_pozhilogo_vozrasta_klinich/


About the Author

Natalia A. Cherkasova 1 , Irina S. Komarova 1 , Nadezhda V. Mukhina 1 , Nikita V. Dyatlov 1

1 Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia

References

1. ESC/EAS Guidelines for the management of dyslipidaemias 2019: lipid modification to reduce cardiovascular risk. Eur Heart J 2019; 00: 1–78. DOI: 10.1093/eurheartj/ehz455
2. Rosengren A. Better treatment and improved prognosis in elderly patients with AMI: but do registers tell the whole truth? Eur Heart J 2012; 33 (5): 562–3. DOI: 10.1093/eurheartj/ehr364
3. Prospective Studies C, Lewington S, Whitlock G et al. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet 2007; 370 (9602): 1829–39. DOI: 10.1016/ S0140–6736(07)61778–4
4. Thompson PD, Panza G, Zaleski A, Taylor B. Statin-Associated Side Effects. J Am Coll Cardiol 2016; 67 (20): 2395–410. DOI: 10.1016/j.jacc.2016.02.071
5. Statin side effects: Weigh the benefits and risks. Mayo Clinic Staff 2016. URL: mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statin-side-effects/art-20046013?pg=1
6. Драпкина О.М., Чернова Е.М. Миопатия как побочный эффект терапии статинами: механизмы развития и перспективы лечения. Рациональная фармакотерапия в кардиологии. 2015; 1. [Drapkina O.M., Chernova E.M. Myopathy as a side effect of statin therapy: mechanisms of development and treatment prospects. Ratsional'naia farmakoterapiia v kardiologii. 2015; 1 (in Russian).]
7. Rosenson RS et al. Statin muscle-related adverse events. Accessed Jan. 25, 2019. URL: https://www.uptodate.com/contents/search.
8. Напалков Д.А. Безопасность статинов: что нужно знать практикующему врачу. Рациональная фармакотерапия в кардиологии. 2014; 10 (3); 334–8.
[Napalkov D.A. Bezopasnost' statinov: chto nuzhno znat' praktikuiushchemu vrachu. Ratsional'naia farmakoterapiia v kardiologii. 2014; 10 (3); 334–8 (in Russian).]
9. Hansen KE., Hildebrand JP, Ferguson EE et al. Arch Intern Med 2005; 165: 2671–6.
10. Bruckert E, Hayem G, Dejager S et al. Cardiovasc Drugs Ther. 2005; 19: 403–14; Cholesterol Treatment Trialists (CTT) Cjllaboration. Efficacy and safety of more intensive lovering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials. Lancet 2010; 376; 1670–80.
11. Bruckert E, Hayem G, Dejager S et al. Mild to Moderate Muscular Symptoms with High-Dosage Statin Therapy in Hyperlipidemic Patients – The PRIMO Study. Cardiovasc Drugs Ther 2005; 19 (6): 403–14. DOI: 10.1007/s10557-005-5686-z
12. Langeard A, Saillant K, Cloutier EC et al. Association between Statin Use and Balance in Older Adults. Int J Environ Res Public Health 2020; 17 (13): 4662. DOI: 10.3390/ijerph17134662
13. Rothschild DP, Novak E, Rich MW. Effect of Statin Therapy on Mortality in Older Adults Hospitalized with Coronary Artery Disease: A Propensity-Adjusted Analysis. J Am Geriatr Soc 2016; 64 (7): 1475–9.

Портал CON-MED.RU:
https://con-med.ru/magazines/klinicheskiy_razbor_v_obshchey_meditsine/klinicheskiy_razbor_v_obshchey_meditsine-10-2021/statin_indutsirovannaya_miopatiya_na_fone_priema_atorvastatina_u_patsienta_pozhilogo_vozrasta_klinich/


For citation:Cherkasova N.A., Komarova I.S., Mukhina N.V., Dyatlov N.V.. Statin-induced myopathy associated with atorvastatin therapy in the elderly patient. Clinical case. Clinical review for general practice. 2021; 10: 10–13. DOI: 10.47407/kr2021.2.10.00112


All accepted articles publish licensed under a Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

  • About
  • Editorial board
  • Ethics
  • For authors
  • Author fees
  • Peer review
  • Contacts

oa
crossref
анри


  Indexing

doaj
elibrary

Address of the Editorial Office:

127055, Moscow, s/m 37

Correspondence address:

115054, Moscow, Zhukov passage, 19, fl. 2, room XI


Managing Editor:

+7 (495) 926-29-83

id@con-med.ru