Clinical review for general practice

ISSN (Print) 2713-2552
ISSN (Online) 2782-5671
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FULLSCREEN > Archive > 2021 > Vol 2, №1 (2021) > Systemic lupus erythematosus or lupus-like syndrome in patients with HIV infection: clinical case review

Systemic lupus erythematosus or lupus-like syndrome in patients with HIV infection: clinical case review

Margarita A. Gromova

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  • Abstract
  • About the Author
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Abstract

Background. Due to multi-organ lesions and a wide range of clinical manifestations, human immunodeficiency virus (HIV infection) resembles systemic connective tissue diseases, particularly systemic lupus erythematosus (SLE). Similarity of immune disorders in patients with HIV infection and SLE may lead to misdiagnosis resulting in wrong tactics of treatment (prescribing immunosuppressive therapy instead of high-dose antiretroviral therapy).
Aim. To report the HIV infection and SLE differential diagnosis challenges.
Results. By January 2021, the analysis of national literature revealed two cases of HIV infection in young women, initially misdiagnosed with suspected SLE. In addition to two patients described in literature, one more female patient with SLE manifestations combined with advanced stage of HIV infection was examined.
Conclusion. HIV and SLE differential diagnosis is the ultimate challenge for clinicians. Physicians should be especially apprehensive about HIV infection when making the diagnosis of SLE. SLE therapy in patients with HIV infection should be appointed according to strict indications.

Key words: systemic lupus erythematosus, human immunodeficiency virus (HIV), acquired immunodeficiency syndrome (AIDS), articular syndrome.

About the Author

Margarita A. Gromova 1

1 Pirogov Russian National Research Medical University, Moscow, Russia

References

1. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/hiv-aids
2. VICh-infektsiia v Rossiiskoi Federatsii na 31 oktiabria 2019 g. [Elektronnyi resurs]. URL: http://aids-centr.perm.ru/images/4/ hiv_in_russia/hiv_in_rf_31.10.2019.pdf.pdf (in Russian).
3. Bakshi J, Ismajli M, Rahman A. New therapeutic avenues in SLE. Best Pract Res Clin Rheumatol 2015; 29 (6): 794–809. DOI: 10.1016/j.berh.2016.02.007
4. Alekseeva E.I., Dvoriakovskaia T.M., Nikishina I.P. et al. Sistemnaia krasnaia volchanka: klinicheskie rekomendatsii. Chast' 1. Voprosy sovremennoi pediatrii. 2018; 17 (1): 19–37. DOI: 10.15690/vsp. v17i1.1853 (in Russian).
5. Virot E, Duclos A, Adelaide L et al. Autoimmune diseases and HIV infection: A cross-sectional study. Medicine (Baltimore) 2017; 96 (4): e5769. DOI: 10.1097 /MD.0000000000005769
6. Puzanova O.G. Revmaticheskie maski VICh-infektsii. Vnutrenniaia meditsina. 2007; 4 (4). http://www.mif-ua.com/archive/article/ 2838 (in Russian).
7. Bukhanova D.V., Belov B.S. Porazhenie sustavov pri VICh-infektsii. Meditsinskii sovet. 2018; (9): 82–7. DOI:10.21518/2079-701X-2018-9-82-87 (in Russian).
8. Skriabina E.N., Magdeeva N.A., Nam I.F. Sistemnaia krasnaia volchanka ili volchanochnopodobnaia "maska" VICh-infektsii? Saratovskii nauchno-meditsinskii zhurnal 2009; 5 (3): 444–6. (in Russian).
9. Sigidin Ia.A., Guseva N.G., Ivanova M.M. Diffuznye bolezni soedinitel'noi tkani (Sistemnye revmaticheskie zabolevaniia): rukovodstvo dlia vrachei. Moscow: Meditsina, 2004 (in Russian).
10. Ponomareva E.Iu., Shul'diakov A.A., Anashchenko A.V., Rebrov A.P. Klinicheskaia manifestatsiia VICh-infektsii, imitiruiushchaia revmaticheskie zabolevaniia. Nauchno-prakticheskaia revmatologiia. 2018; 56 (4): 525–530. DOI: 10.14412/1995-4484-2018-525-530 (in Russian).
11. Kamnerer R, Burgisser P, Frei Pc. Anti-human immunodeficiency virus type I antibodies of noninfected subjects are not related to antibodies occurring in systemic diseases. Clin Dign Lab Immunol 1995; 2(4): 458–61. DOI: 10.1128/cdli.2.4.458-461.1995
12. Evans-Jones JG, Cottle LE, Back DJ et al. Recognition of risk for clinically significant drug interactions among HIV-infected patients receiving antiretroviral therapy. Clin Infec Dis 2010; 50 (10): 1419–21. DOI: 10.1086/652149
13. Fox C, Walker-Bone K. Evolving spectrum of HIV-associated rheumatic syndromes. Best Pract Res Clin Rheumatol 2015: 29 (2): 244–58. DOI: 10.1016/j.berh.2015.04.019
14. Diana NE, Naicker S. Update on current management of chronic kidney disease in patients with HIV infection. Int J Nephrol Renovasc Dis 2016; 9: 223–34. DOI: 10.2147/IJNRD.S93887
15. Solov'ev S.K., Aseeva E.A., Popkova T.V. et al. Sistemnaia krasnaia volchanka: novye gorizonty diagnostiki i terapii. Nauchno-prakticheskaia revmatologiia. 2020; 58 (1): 5–14. DOI: 10.14412/1995-4484-2020-5-14 (in Russian).

For citation:Gromova M.A. Systemic lupus erythematosus or lupus-like syndrome in patients with HIV infection: clinical case review. Clinical review for general practice. 2021; 1: 22–27. DOI: 10.47407/kr2021.2.1.00029


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