Современные механизмы защиты эпителия дыхательных путей

Для цитирования:

Аннотация

N-ацетилцистеин (Флуимуцил) отличается высоким антиоксидантным потенциалом как за счет прямого влияния на свободные радикалы, ингибируя свободнорадикальные реакции, в том числе связанные с механизмами железозависимой клеточной смерти (ферро-птоз), так и на процессы синтеза антиоксидантных молекул, формирующих систему антиоксидантной защиты. В обзоре особое внимание уделено участию N-ацетилцистеина в формировании антиоксидантной защиты и использованию его в режиме высоких доз в комбинации с тиамфениколом в лечении бактериальных инфекций.
Ключевые слова: эпителий дыхательных путей, воспалительные заболевания легких, бактериальные инфекции, N-ацетилцистеин.

Список литературы

1. Pawankar R, Canonica GW, Holgate ST, Lockey RF. Allergic diseases and asthma: a major global health concern. Curr Opin Allergy Clin Immunol 2012;12(1):39-41. DOI: 10.1097/ACI.0b013e32834ec13b. PMID: 22157151.

2. Lozano R, Naghavi M, Foreman K et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380(9859):2095-128. DOI: 10.1016/S0140-6736(12)61728-0. Erratum in: Lancet. 2013 Feb 23;381(9867):628.

3. Li X, Cao X, Guo M et al. Trends and risk factors of mortality and disability adjusted life years for chronic respiratory diseases from 1990 to 2017: systematic analysis for the Global Burden of Disease Study 2017. BMJ 2020;368:m234. DOI: 10.1136/bmj.m234. Erratum in: BMJ 2020;370:m3150. DOI: 10.1136/bmj.m3150. PMID: 32075787; PMCID: PMC7190065.

4. Abohalaka R. Bronchial epithelial and airway smooth muscle cell interactions in health and disease. Heliyon 2023;9(9):19976. DOI: 10.1016/j.heliyon.2023.e19976

5. Yan F. Roles of airway smooth muscle dysfunction in chronic obstructive pulmonary disease. J Transl Med 2018;(16):262.

6. Tankut G et al. Epithelial-stromal cell interactions and extracellular matrix mechanics drive the formation of airway-mimetic tubular morphology in lung organoids. iScience 2021;24(9):103061.

7. Humayun M, Chow CW, Young EWK. Microfluidic lung airway-on-a-chip with arrayable suspended gels for studying epithelial and smooth muscle cell interactions. Lab Chip 2018;18(9):1298-309. DOI: 10.1039/c7lc01357d. PMID: 29651473.

8. Burgoyne RA, Fisher AJ, Borthwick LA. The Role of Epithelial Damage in the Pulmonary Immune Response. Cells 2021;10(10):2763. DOI: 10.3390/cells10102763. PMID: 34685744; PMCID: PMC8534416.

9. Carmo-Fernandes A, Puschkarow M, Peters K et al. The Pathogenic Role of Smooth Muscle Cell-Derived Wnt5a in a Murine Model of Lung Fibrosis. Pharmaceuticals 2021;14(8):755.

10. Sauleda J, Núñez B, Sala E, Soriano JB. Idiopathic Pulmonary Fibrosis: Epidemiology, Natural History, Phenotypes. Med Sci (Basel) 2018;6(4):110. DOI: 10.3390/medsci6040110. PMID: 30501130; PMCID: PMC6313500.

11. Fain SB, Altes TA, Panth SR et al. Detection of age-dependent changes in healthy adult lungs with diffusion-weighted 3He MRI. Acad Radiol 2005;12:1385-93.

12. Godin LM, Sandri BJ, Wagner DE et al. Decreased Laminin Expression by Human Lung Epithelial Cells and Fibroblasts Cultured in Acellular Lung Scaffolds from Aged Mice. PLoS ONE 2016;(11):e0150966.

13. Schneider JL, Rowe JH, Garcia-de-Alba C et al. The aging lung: Physiology, disease, and immunity. Cell 2021;184(8):1990-2019. DOI: 10.1016/j.cell.2021.03.005. Epub 2021 Apr 2. PMID: 33811810; PMCID: PMC8052295.

14. Ascher K, Elliot SJ, Rubio GA, Glassberg MK. Lung Diseases of the Elderly: Cellular Mechanisms. Clin Geriatr Med 2017;33(4):473-90. DOI: 10.1016/j.cger.2017.07.001. Epub 2017 Aug 18. PMID: 28991645.

15. Carter P, Lagan J, Fortune C et al. Association of Cardiovascular Disease With Respiratory Disease. J Am Coll Cardiol 2019;73(17):2166-77. DOI: 10.1016/j.jacc.2018.11.063

16. Shen L, Jhund PS, Anand IS et al. Incidence and Outcomes of Pneumonia in Patients With Heart Failure. J Am Coll Cardiol 2021;77(16):1961-73. DOI: 10.1016/j.jacc.2021.03.001

17. Forman HJ, Zhang H. Targeting oxidative stress in disease: promise and limitations of antioxidant therapy. Nat Rev Drug Discov 2021;20(9):689-709. DOI: 10.1038/s41573-021-00233-1. Epub 2021 Jun 30. Erratum in: Nat Rev Drug Discov 2021;20(8):652. DOI: 10.1038/s41573-021-00267-5. PMID: 34194012; PMCID: PMC8243062.

18. Beavers WN, Skaar EP. Neutrophil-generated oxidative stress and protein damage in Staphylococcus aureus. Pathog Dis 2016;74(6):ftw060. DOI: 10.1093/femspd/ftw060. Epub 2016 Jun 27. PMID: 27354296; PMCID: PMC5975594.

19. Sathe N, Beech P, Croft L et al. Pseudomonas aeruginosa: Infections and novel approaches to treatment «Knowing the enemy» the threat of Pseudomonas aeruginosa and exploring novel approaches to treatment. Infect Med (Beijing) 2023;2(3):178-94. DOI: 10.1016/j.imj. 2023.05.003

20. Qin S, Xiao W, Zhou C et al. Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics. Signal Transduct Target Ther 2022;7(1):199. DOI:10.1038/s41392-022-01056-1

21. Dailah HG. Therapeutic Potential of Small Molecules Targeting Oxidative Stress in the Treatment of Chronic Obstructive Pulmonary Disease (COPD): A Comprehensive Review. Molecules 2022;27(17):5542. DOI: 10.3390/molecules27175542. PMID: 36080309; PMCID: PMC9458015.

22. Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview. Sci World J 2013;(2013):16. DOI: 10.1155/2013/162750. 162750

23. Gould NS, Day BJ. Targeting maladaptive glutathione responses in lung disease. Biochem Pharmacol 2011;81(2):187-93. DOI: 10.1016/ j.bcp.2010.10.001

24. Ghezzi P. Protein glutathionylation in health and disease. Biochim Biophys Acta 2013;1830(5):3165-72. DOI: 10.1016/j.bbagen.2013.02.009

25. Santus P, Signorello JC, Danzo F et al. Anti-Inflammatory and Anti-Oxidant Properties of N-Acetylcysteine: A Fresh Perspective. J Clin Med 2024;(13):4127. DOI: 10.3390/jcm13144127

26. Moldéus P, Cotgreave IA, Berggren M. Lung protection by a thiol-containing antioxidant: N-acetylcysteine. Respiration 1986;50(Suppl.1): 31-42. DOI: 10.1159/000195086

27. Tenório MCDS, Graciliano NG, Moura FA et al. N-Acetylcysteine (NAC): Impacts on Human Health. Antioxidants (Basel) 2021;10(6): 967. DOI: 10.3390/antiox10060967

28. Santus P, Corsico A, Solidoro P et al. Oxidative stress and respiratory system: pharmacological and clinical reappraisal of N-acetylcysteine. COPD 2014;11(6):705-17. DOI: 10.3109/15412555.2014.898040

29. Rushworth GF, Megson IL. Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits. Pharmacol Ther 2014;141(2):150-9. DOI: 10.1016/j.pharmthera.2013.09.006. Epub 2013 Sep 28.

30. Zhao T, Liu Y. N-acetylcysteine inhibit biofilms produced by Pseudomonas aeruginosa. BMC Microbiol 2010;(10):140. DOI: 10.1186/1471-2180-10-140

31. Izquierdo JL, Soriano JB, González Y et al. Use of N-Acetylcysteine at high doses as an oral treatment for patients hospitalized with COVID-19. Sci Prog 2022;105(1):368504221074574. DOI: 10.1177/0036850422107 4574. PMID: 35084258; PMCID: PMC8795755.

32. Jiang X, Stockwell BR, Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 2021;22(4):266-82. DOI: 10.1038/s41580-020-00324-8. Epub 2021 Jan 25.

33. Dar HH, Anthonymuthu TS, Ponomareva LA et al. A new thiol-independent mechanism of epithelial host defense against Pseudomonas aeruginosa: iNOS/NO – sabotage of theft-ferroptosis. Redox Biol 2021;45:102045. DOI: 10.1016/j.redox.2021.102045. Epub 2021 Jun 16. PMID: 34167028; PMCID: PMC8227829.

34. Kapralov AA, Yang Q, Dar HH et al. Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Nat Chem Biol 2020;16(3):278-90. DOI: 10.1038/s41589-019-0462-8. Epub 2020 Feb 17. PMID: 32080625; PMCID: PMC7233108

35. Del Pozo JL. Biofilm-related disease. Expert Rev Anti Infect Ther 2018;16(1):51-65. DOI: 10.1080/14787210.2018.1417036. Epub 2017 Dec 19.

36. Blasi F, Page C, Rossolini GM et al. The effect of N-acetylcysteine on biofilms: Implications for the treatment of respiratory tract infections. Respir Med 2016;(117):190-7. DOI: 10.1016/j.rmed.2016.06.015. Epub 2016 Jun 16.

37. Vance RE, Hong S, Gronert K et al. The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase. Proc Natl Acad Sci U S A 2004;101(7):2135-9. DOI: 10.1073/pnas. 0307308101. Epub 2004 Feb 6.

38. Dar HH, Epperly MW, Tyurin VA et al. P. aeruginosa augments irradiation injury via 15-lipoxygenase-catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis. JCI Insight 2022;7(4):e156013. DOI: 10.1172/jci.insight.156013

39. Иванчик Н.В., Сухорукова М.В., Чагарян А.Н. и др. In vitro активность тиамфеникола в отношении клинических изолятов Haemophilus influenzae, Streptococcus pneumoniae и Streptococcus pyogenes. Клиническая микробиология и антимикробная химиотерапия. 2021;23(1):92-9.

Ivanchik N.V., Sukhorukova M.V., Chagaryan A.N., et al. In vitro activity of thiamphenicol against clinical isolates of Haemophilus influenzae, Streptococcus pneumoniae, and Streptococcus pyogenes. Clinical Microbiology and Antimicrobial Chemotherapy. 2021;23(1):92-9 (in Russian).

40. Drago L, Fassina MC, Mombelli B et al. Comparative effect of thiamphenicol glycinate, thiamphenicol glycinate N-acetylcysteinate, amoxicillin plus clavulanic acid, ceftriaxone and clarithromycin on pulmonary clearance of Haemophilus influenzae in an animal model. Chemotherapy 2000;46(4):275-81. DOI: 10.1159/000007299

41. Постников С.С., Грацианская А.Н. Ингаляционная терапия при респираторных инфекциях: Флуимуцил антибиотик ИТ. Практика педиатра. 2016;(3):56-9.

Postnikov S.S., Gratsianskaya A.N. Inhalation therapy for respiratory infections: Fluimucil antibiotic IT. Pediatrician Practice 2016;3:56-9 (in Russian).

42. Brandenberger C, Mühlfeld C. Mechanisms of lung aging. Cell Tissue Res 2017;367(3):469-80. DOI: 10.1007/s00441-016-2511-x. Epub 2016 Oct 14. PMID: 27743206.

Для цитирования:Пономарева Л.А., Зубарев И.С., Бернс С.А., Чинова А.А., Попова Е.Н. Современные механизмы защиты эпителия дыхательных путей. Клинический разбор в общей медицине. 2024; 5 (11): 76–82. DOI: 10.47407/kr2024.5.11.00520

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Клинический разбор в общей медицине