Клинический разбор в общей медицине

Оксидативный стресс (ОС) патогенетически объединяет триаду наиболее распространенных заболеваний предстательной железы (ПЖ), которую составляют хронический простатит, доброкачественная гиперплазия и рак ПЖ. ОС – это состояние нарушенного баланса между образованием активных форм кислорода и эффективностью антиоксидантов. Антиоксидантная система, включающая ферментативные факторы (супероксиддисмутаза, каталаза и глутатионпероксидаза), неферментативные факторы и низкомолекулярные соединения (глутатион, N-ацетилцистеин, витамины E, A и C, коэнзим Q10, карнитины, мио-инозитол, ликопин и др.), а также микроэлементы (селен, цинк и медь), защищают организм от ОС. Недостаток одного из них приводит к снижению антиоксидантной способности плазмы. Назначение антиоксидантной терапии больным с хроническим простатитом, доброкачественной гиперплазией и рак ПЖ патогенетически обосновано, что подтверждает проведенный критический анализ отечественной и зарубежной литературы.

Ключевые слова: простатит, доброкачественная гиперплазия предстательной железы, рак предстательной железы, антиоксиданты, селен, цинк, Селцинк.

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