Clinical review for general practice

ISSN (Print) 2713-2552
ISSN (Online) 2782-5671
  • Home
  • about
  • archives
  • contacts
left
FULLSCREEN > Archive > 2021 > Role of trace mineral deficiencies in decreased fertility and infertility (clinical lecture)

Role of trace mineral deficiencies in decreased fertility and infertility (clinical lecture)

Vladimir V. Borisov

For citation:


  • Abstract
  • About the Author
  • References

Abstract

The clinical lecture is a continuation of our report on antioxidants published in one of the preceding issues of the magazine. In the current context of COVID-19 epidemic, the efforts to struggle for preservation of human life and health using all possible sanitary and anti-epidemic (preventive) measures, as well as advanced diagnostic and therapeutic tools, imply fertility preservation in the population together with positive solutions to national demographic challenges in the long term. Testicles are one of the reservoirs for the virus in the male body. This is indirectly confirmed by the sex hormone level alterations in COVID-19 survivors compared to healthy people. Oxidative stress associated with impaired fertility results from antioxidant and trace mineral deficiency. The role of trace minerals, zinc and selenium, in these processes together with possible approaches to adjustment of their levels in the context of COVID-19 pandemic are discussed in detail.

Key words: trace minerals, COVID-19 pandemic, fertility, sexual constitution, blood–testis barrier, zinc deficiency, selenium deficiency, treatment of zinc and selenium deficiency.

About the Author

Vladimir V. Borisov 1

1 Russian Society of Urologists, Moscow, Russia

References

1. Pan F, Xiao X, Guo J et al. No evidence of severe acute respiratory syndrome- coronavirus 2 in semen of males recovering from coronavirus disease 2019. Fertil Steril 2020; 113 (6): 1135–9. 
2. Dodson R., Elliot U., Dzhons K. Spravochnik biokhimika. Moscow: Mir, 1991. P. 543. (in Russian).
3. Kerns K, Zigo M, Sutovsky P. Zinc: a necessary ion for mammalian sperm fertilization competency. Int J Moleculas Scien 2018; 19: 4097. DOI: 10.3390/ijms19124097 
4. Dhanda OP, Rao BR, Razdan MN. Sorbitol dehydrogenase and hyaluronidase activity in buffalo semen. Indian J Exp Biol 1981; 19: 286. 
5. Andreini C, Banci L, Bertini I, Rosato A. Counting the zinc-proteins encoded in the human genome. J Proteome Res 2006; 5: 196–201.
6. Vallee BL, Coleman JE, Auld DS. Zinc fingers, zinc clusters, and zinc twists in DNA-binding protein domains. Proc Natl Acad Sci USA 1991; 88: 999–1003.
7. Wu J, Wu S, Xie Y et al. Zinc protects sperm from being damaged by reactive oxygen species in assisted reproduction techniques. Reprod Biomed Online 2015; 30 (4): 334–9. DOI: 10.1016/j.rbmo.2014 .12.008 
8. Guidobaldi HA, Cubilla M, Moreno A et al. Sperm chemorepulsion, a supplementary mechanism to regulate fertilization. Human reproduction 2017: 1–14. DOI: 10.1093/dex232 
9. Giacone F, Condorelli RA, Mongioì LM et al. In vitro effects of zinc, D-aspartic acid, and coenzyme-Q10 on sperm function. Endocrine 2017; 56 (2): 408–15. DOI: 10.1007/s12020-016-1013-7 
10. Talevi R, Barbato V, Fiorentino I et al. Protective effects of in vitro treatment with zinc, d-aspartate and coenzyme q10 on human sperm motility, lipid peroxidation and DNA fragmentation. Reprod Biol Endocrinol 2013; 11: 81. DOI: 10.1186/1477-7827-11-81 
11. Goodarzi D, Cyrus A, Baghinia MR et al. The efficacy of zinc for treatment of chronic prostatitis. Indonesian J Int Med 2013; 45 (4): 259–2. 
12. Ann VI, Sandhya K, Ramya N et al. Supplementing zinc oxide nanoparticles to cryopreservation medium minimizes the freeze-thaw-induced damage to spermatozoa. Biochem Biophys Res Commun 2017; 494 (3–4): 656–62. DOI: 10.1016/j.bbrc.2017.10.112
13. Commission Directive 2008/100/EC of 28 October 2008 amending Council Directive 90/496/EEC on nutrition labeling for foodstuffs as regards recommended daily allowances, energy conversion factors and definitions. Official J Eur Union 2008; 285 (9): 1–4.
14. Zinc deficiency may play a role in high blood pressure. Science Daily, 2019.
15. Zini A, Garrels K, Phang D. Antioxidant activity in the semen of fertile and infertile men. Urology 2000; 55: 922–6.
16. Korovina N.A. Profilaktika rakhita u detei: primenenie kal'tsiia. Lechashchii vrach. 2004; 1: 56–8 (in Russian).
17. http://www.selzink.ru/ 
18. Aartjan J W te Velthuis et al. Zn2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. PLoS Pathog 2010; 6 (11): e1001176. 
19. Junaidah BB,  Davidson HH,  Simin NM. Low zinc status: a new risk factor for pneumonia in the elderly? Nutr Rev 2010; 68 (1): 30–7. 
20. https://www.sechenov.ru/pressroom/news/tsink-selen-i-vitamin-d-kak-zashchishchatsya-ot-covid-19/. 

For citation:Borisov V.V. Role of trace mineral deficiencies in decreased fertility and infertility (clinical lecture). Clinical review for general practice. 2021; 4: 64–70. DOI: 10.47407/kr2021.2.4.00062


All accepted articles publish licensed under a Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

  • About
  • Editorial board
  • Ethics
  • For authors
  • Author fees
  • Peer review
  • Contacts

oa
crossref
анри


  Indexing

doaj
elibrary

Address of the Editorial Office:

127055, Moscow, s/m 37

Correspondence address:

115054, Moscow, Zhukov passage, 19, fl. 2, room XI


Managing Editor:

+7 (495) 926-29-83

id@con-med.ru