A clinical case of a pulmonary tuberculosis/mycobacteriosis mixed infection

Anna P. Sargsyan , Natalya N. Makaryants , Larisa N. Lepekha , Natalya G. Demyanenko

For citation:

Abstract

Nontuberculous mycobacteriosis is an infectious disease caused by nontuberculous mycobacteria (NTM) with the development of granulomatous inflammation in affected organs and tissues. By now more than 200 NTM species persisting in the environment have been described. According to different authors, 30 to 60 of strains are able to cause disease in humans. It was established that patients with different chronic lung diseases: chronic bronchitis, chronic obstructive pulmonary disease, and bronchiectatic lung disease are predisposed to mycobacteriosis. Recently, cases of pulmonary TB/NTM infection have been reported more and more frequently, which impedes timely verification of both diseases. Diagnosis of coinfection is essentially facilitated by morphological studies of lung tissue, which can simultaneously assess signs of TB and/or NTM infection. The article describes a clinical case of mixed pulmonary infection with NTM and Mycobacterium tuberculosis.

Keywords: mixed infection, nontuberculous mycobacteriosis, pulmonary TB.

References

1. Гунтупова Л.Д., Борисов С.Е., Соловьева И.П. и др. Микобактериозы во фтизиопульмонологической практике: обзор литературы и собственный опыт. Практическая медицина. 2011; 3 (51): 39–50. [Guntupova L.D., Borisov C.E., Solovyova I.P. et al. Mycobacterioses in phthisiopulmonological practice: literature review and own experience. Practical medicine. 2011; 3 (51): 39–50 (in Russian).]

2. Литвинов В.И. Нетуберкулезные микобактерии, микобактериозы. Вестник ЦНИИТ. 2018; 2: 5–20. [Litvinov V.I. Nontuberculous mycobacteria, mycobacterioses. TsNIIT Bulletin. 2018; 2: 5–20 (in Russian).]

3. Степанян И.Э., Багдасарян Т.Р., Ларионова Е.Е. и др. Туберкулез и микобактериоз легких у одного пациента: особенности диагностики и лечения. Вестник Центрального научно-исследовательского института туберкулеза. 2019; 1: 84–90. [Stepanyan I.E., Baghdasaryan T.R., Larionova E.E. et al. Tuberculosis and mycobacteriosis of the lungs in one patient: peculiarities of diagnosis and treatment. Bulletin of the Central Tuberculosis Research Institute. 2019; 1: 84–90 (in Russian).]

4. Шмелев Е.И., Ковалевская М.Н., Эргешов А.Э. и др. Микобактериозы в практике врача-пульмонолога: состояние проблемы. Практическая пульмонология. 2016; 3: 37–43. [Shmelev E.I., Kovalevskaya M.N., Ergeshov A.E. et al. Mycobacterioses in the practice of a pulmonologist: the state of the problem. Practical pulmonology. 2016; 3: 37–43 (in Russian).]

5. Эргешов А.Э., Шмелев Е.И., Ковалевская М.Н. и др. Нетуберкулезные микобактерии у пациентов с заболеваниями органов дыхания (клинико-лабораторное исследование). Пульмонология. 2016; 26 (3): 303–8. Литература / References | КЛИНИЧЕСКИЙ РАЗБОР В ОБщЕЙ МЕДИЦИНЕ | ТОМ 4 | №2 | 2023 | Clinical review for general practice | vol. 4 | no. 2 | 2023 | 47 Клинический случай / Clinical Case [Ergeshov A.E., Shmelev E.I., Kovalevskaya M.N. et al. Non-tuberculous mycobacteria in patients with respiratory diseases (clinical and laboratory study). Pulmonology. 2016; 26 (3): 303–8 (in Russian).]

6. Andréjak C, Nielsen R, Thomsen VØ et al. Chronic respiratory disease, inhaled corticosteroids and risk of non-tuberculous mycobacteriosis. Thorax 2013; 68 (3): 256–62.

7. Balavoine C, Andréjak C, Marchand-Adam S, Blanc FX. Relations entre la BPCO et les infections à mycobactéries non tuberculeuses [Relationships between COPD and nontuberculous mycobacteria pulmonary infections]. Rev Mal Respir 2017; 34 (10): 1091–7.

8. Chin KL, Sarmiento ME, Alvarez-Cabrera N et al. Pulmonary non-tuberculous mycobacterial infections: current state and future management. Eur J Clin Microbiol Infect Dis 2020; 39 (5): 799–826.

9. Marras TK, Daley CL. Epidemiology of human pulmonary infection with nontuberculous mycobacteria. Clin Chest Med 2002; 23 (3): 553–67.

10. Prevots DR, Marras TK. Epidemiology of human pulmonary infection with nontuberculous mycobacteria: a review. Clin Chest Med 2015; 36 (1): 13–34.

11. Ringshausen FC, Wagner D, de Roux A et al. Prevalence of Nontuberculous Mycobacterial Pulmonary Disease, Germany, 2009–2014. Emerg Infect Dis 2016; 22 (6): 1102–5.

12. Jeon D. Infection Source and Epidemiology of Nontuberculous Mycobacterial Lung Disease. D Jeon Tuberc Respir Dis (Seoul) 2019; 82 (2): 94–101.

13. Jones MM, Winthrop KL, Nelson SD et al. Epidemiology of nontuberculous mycobacterial infections in the U.S. Veterans Health Administration. PLoS One 2018; 13 (6): e0197976.

14. Амансахедов Р.Б., Лепеха Л.Н., Дмитриева Л.И. и др. Рентгенморфологическая семиотика нетуберкулезных микобактериозов легких. Вестник рентгенологии и радиологии. 2018; 99 (4): 184–90. [Amansakhedov R.B., Lepekha L.N., Dmitrieva L.I. et al. X-ray morphological semiotics of non-tuberculous mycobacteriosis of the lungs. Bull Radiology Radiology 2018; 99 (4): 184–90 (in Russian).]

15. Лепеха Л.Н., Красникова Е.В., Макарьянц Н.Н. и др. Тканевые и клеточные реакции легких, вызванные различными штаммами медленнорастущих нетуберкулезных микобактерий. Вестник Центрального научно-исследовательского института туберкулеза. 2020; 4: 27–34. [Lepekha L.N., Krasnikova E.V., Makaryants N.N. et al. Tissue and cellular lung responses caused by different strains of slow-growing nontuberculous mycobacteria. Bulletin of the Central Tuberculosis Research Institute. 2020; 4: 27–34 (in Russian).]

16. Михайловский А.М., Чуркин С.А., Пашкова Н.А., Лепеха Л.Н. Частота выявления и особенности морфологии нетуберкулезного микобактериоза у больных на поздней стадии ВИЧ-инфекции (по данным Оренбургской области). Туберкулез и болезни легких. 2016; 94 (12): 57–61. [Mikhailovsky A.M., Churkin S.A., Pashkova N.A., Lepekha L.N. Frequency of detection and peculiarities of morphology of nontuberculous mycobacteriosis in patients at an advanced stage of HIV infection (according to the Orenburg region). Tuberculosis and lung diseases. 2016; 94 (12): 57–61 (in Russian).]

17. Саргсян А.П., Макарьянц Н.Н., Лепеха Л.Н. и др. Сложности дифференциальной диагностики микобактериоза легких, вызванного M. abscessus. Вестник Центрального научно-исследовательского института туберкулеза. 2020; 4: 81–7. [Sargsyan A.P., Makaryants N.N., Lepekha L.N. et al. Difficulties of differential diagnosis of mycobacteriosis of the lungs caused by M. abscessus. Bulletin of the Central Tuberculosis Research Institute. 2020; 4: 81–7 (in Russian).]

For citation:Sargsyan A.P., Makaryants N.N., Lepekha L.N., Demyanenko N.G. A clinical case of a pulmonary tuberculosis/mycobacteriosis mixed infection. Clinical review for general practice. 2023; 4 (2): 43–47. DOI: 10.47407/kr2023.4.2.00203

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Clinical review for general practice