Clinical review for general practice

ISSN (Print) 2713-2552
ISSN (Online) 2782-5671
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FULLSCREEN > Archive > 2023 > Vol 4, №3 (2023) > Pregnancy management in a woman with inherited thrombophilia, personal history of preeclampsia and family history of eclampsias

Pregnancy management in a woman with inherited thrombophilia, personal history of preeclampsia and family history of eclampsias

Lidiya O. Buzyan

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  • Abstract
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Abstract

One of the most important aspects of reducing the incidence of preeclampsia is the most complete and timely assessment of risk factors for each patient. One of the well-known, but often overlooked, risk factors is a family history of preeclampsia. In the history of our patient during her first pregnancy the fact of her mother’s eclampsia was ignored, antithrombotic medication were not prescribed, and the pregnancy has ended in premature birth due to severe preeclampsia. The examination confirmed inherited thrombophilia – Leiden mutation. The next pregnancy was managed with appointment of antithrombotic medication – low molecular weight heparin and low doses of acetylsalicylic acid, without complications and ended in timely delivery. 
Key words: preeclampsia, thrombophilia, Leiden mutation, acetylsalicylic acid, low molecular weight heparin, preterm birth.

About the Author

Lidiya O. Buzyan 1

1 Centre for Reproductive Medicine and Genetics "Nova Clinic", Moscow, Russia

References

1. Преэклампсия. Эклампсия. Отеки, протеинурия и гипертензивные расстройства во время беременности, в родах и послеродовом периоде. Клинические рекомендации Минздрава России. 2021. [Preeclampsia. Eclampsia. Edema, proteinuria and hypertensive disorders during pregnancy, childbirth and the postpartum period. Clinical recommendations of the Russian Ministry of Health. 2021 (in Russian).] 
2. Cruz-Lemini M, Vazquez JC, Ullmo J et al. Low-molecular-weight heparin for prevention of preeclampsia and other placenta-mediated complications: a systematic review and meta-analysis. Am J Obstet Gynecol 2022; 226 (2): S1126–S1144.e17. 
3. Baldus S, Rudolph V, Roiss M et al. Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase. Circulation 2006; 113 (15): 1871–8. 
4. Hagmann H, Bossung V, Belaidi AA et al. Low-Molecular Weight Heparin Increases Circulating sFlt-1 Levels and Enhances Urinary Elimination. PloS One 2014.

For citation:Buzyan L.O. Pregnancy management in a woman with inherited thrombophilia, personal history of preeclampsia and family history of eclampsias. Clinical review for general practice. 2023; 4 (3): 12–14. DOI: 10.47407/kr2023.4.3.00216


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