Clinical review for general practice

ISSN (Print) 2713-2552
ISSN (Online) 2782-5671
  • Home
  • about
  • archives
  • contacts
left
FULLSCREEN > Archive > 2023 > Vol 4, №4 (2023) > A personalized approach to antioxidant therapy for treatment of men in infertile couples

A personalized approach to antioxidant therapy for treatment of men in infertile couples

Igor A. Korneyev

For citation:


  • Abstract
  • About the Author
  • References

Abstract

The article reviews current opinion on lifestyle, environmental and general health factors that trigger pathogenetic mechanisms of oxidative stress, leading to spermatozoa damage and a decrease of men reproductive function. The possibility of personalized male infertility restoring by using drugs that neutralize the damaging effect of reactive oxygen species, including the complex of vitamins and microelements Selzinc Plus, containing zinc, selenium, vitamins C, E and beta-carotine is discussed. 
Key words: male infertility, oxidative stress, antioxidant therapy. 

About the Author

Igor A. Korneyev 1

1 Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg, Russia; International Center for Reproductive Medicine, Saint-Petersburg, Russia

References

1. Infertility prevalence estimates, 1990–2021. Geneva: World Health Organization; 2023. Licence: CC BY-NC-SA 3.0 IGO. 
2. Levine H, Jørgensen N, Martino-Andrade A et al. Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries. Hum Reprod Update 2023; 29 (2): 157–76. DOI: 10.1093/humupd/dmac035. PMID: 36377604. 
3. WHO laboratory manual for the examination and processing of human semen. 5th ed. Geneva: World Health Organization, 2010. 
4. WHO laboratory manual for the examination and processing of human semen. 6h ed. Geneva: World Health Organization, 2021. 
5. Boeri L, Belladelli F, Capogrosso P et al. Normal sperm parameters per se do not reliably account for fertility: A case-control study in the real-life setting. Andrologia 2021; 53 (1): e13861. DOI: 10.1111/and.13861. PMID: 33125742. 
6. Божедомов В.А., Николаева М.А., Ушакова И.В. и др. Структура нарушений качества спермы у мужчин из бесплодных пар и алгоритм ведения таких пациентов в специализированных учреждениях третьего уровня. Акушерство и гинекология. 2020; 11: 159–167. DOI: 10.18565/aig.2020.11.159-167 [Bozhedomov V.A., Nikolaeva M.A., Ushakova I.V. et al. Struktura narushenij kachestva spermy u muzhchin iz besplodnyh par i algoritm vedeniya takih pacientov v specializirovannyh uchrezhdeniyah tret'ego urovnya. Akusherstvo i ginekologiya. 2020; 11: 159–167. DOI: 10.18565/aig.2020.11.159-167 (in Russian).] 
7. Agarwal A, Parekh N, Panner Selvam MK et al. Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility. World J Mens Health 2019; 37 (3): 296–312. 
8. Аgarwal A, Allamaneni SS, Said TM. Chemiluminescence technique for measuring reactive oxygen species. Reprod Biomed Online 2004; 9 (4): 466–8. DOI: 10.1016/s1472-6483(10)61284-9. PMID: 15511350. 
9. Walczak-Jedrzejowska R, Wolski JK, Slowikowska-Hilczer J. The role of oxidative stress and antioxidants in male fertility. Cent European J Urol 2013; 66 (1): 60–7. DOI: 10.5173/ceju.2013.01.art19 
10. Kothari S, Thompson A, Agarwal A, du Plessis SS. Free radicals: their beneficial and detrimental effects on sperm function. Indian J Exp Biol 2010; 48 (5): 425–35. PMID: 20795359 
11. Vessey W, Perez-Miranda A, Macfarquhar R et al. Reactive oxygen species in human semen: validation and qualification of a chemiluminescence assay. Fertil Steril 2014; 102 (6): 1576–83.e4. DOI: 10.1016/j.fertnstert.2014.09.009 
12. Roychoudhury S, Sharma R, Sikka S, Agarwal A. Diagnostic application of total antioxidant capacity in seminal plasma to assess oxidative stress in male factor infertility. J Assist Reprod Genet 2016; 33 (5): 627–35. DOI: 10.1007/s10815-016-0677-5
13. Gomes E, Irvine D, Aitken R. Evaluation of a spectrophotometric assay for the measurement of malondialdehyde and 4-hydroxyalkenals in human spermatozoa: Relashionships with semen quality and sperm function. Int J Androl sL 1998; 21: 81–94. DOI: 10.1046/j.1365- 2605.1998.00106.x 
14. Cambi M, Tamburrino L, Marchiani S et al. Development of a specific method to evaluate 8-hydroxy, 2-deoxyguanosine in sperm nuclei: relationship with semen quality in a cohort of 94 subjects. Reproduction 2013; 145 (3): 227–35. DOI: 10.1530/REP-12-0404 
15. Henkel R, Morris A, Vogiatzi P et al. Predictive value of seminal oxidation-reduction potential analysis for reproductive outcomes of ICSI. Reprod Biomed Online 2022; 45 (5): 1007–20. DOI: 10.1016/j.rbmo.2022.05.010 
16. Niu J, Chang Q, Xu J et al. Relationship of the levels of reactive oxygen species in the fertilization medium with the outcome of in vitro fertilization following brief incubation. Front Endocrinol (Lausanne) 2023; 14: 1133566. DOI: 10.3389/fendo.2023.1133566. PMID: 36950698; PMCID: PMC10025477. 
17. Degirmenci Y, Demirdag E, Guler I et al. Impact of the sexual abstinence period on the production of seminal reactive oxygen species in patients undergoing intrauterine insemination: A randomized trial. J Obstet Gynaecol Res 2020; 46 (7): 1133–9. DOI: 10.1111/jog.14308 
18. Sokol P, Drakopoulos P, Polyzos NP. The Effect of Ejaculatory Abstinence Interval on Sperm Parameters and Clinical Outcome of ART. A Systematic Review of the Literature. J Clin Med 2021; 21; 10 (15): 3213. DOI: 10.3390/jcm10153213. PMID: 34361997 
19. Sharma R, Harlev A, Agarwal A, Esteves SC. Cigarette Smoking and Semen Quality: A New Meta-analysis Examining the Effect of the 2010 World Health Organization Laboratory Methods for the Examination of Human Semen. Eur Urol 2016; 70 (4): 635–45. DOI: 10.1016/j.eururo.2016.04.010. PMID: 27113031. 
20. Saleh RA, Agarwal A, Sharma RK et al. Effect of cigarette smoking on levels of seminal oxidative stress in infertile men: a prospective study. Fertil Steril 2002; 78: 491–9. 
21. Dietrich M, Block G, Norkus EP et al. Smoking and exposure to environmental tobacco smoke decrease some plasma antioxidants and increase γ-tocopherol in vivo after adjustment for dietary antioxidant intakes. Am J Clin Nutr 2003; 77: 160–6. 
22. Fuentes A, Muñoz A, Barnhart K et al. Recent cigarette smoking and assisted reproductive technologies outcome. Fertil Steril 2010; 93 (1): 89–95. DOI: 10.1016/j.fertnstert.2008.09.073. PMID: 18973890. 
23. Tummer H, Haberman H, Haas J, Pummer K. The impact of cigarette smoking n huma semen parameters and hormones. Hum Reprod 2002: 16 (6): 1554–9 
24. Finelli R, Mottola F, Agarwal A. Impact of Alcohol Consumption on Male Fertility Potential: A Narrative Review. Int J Environ Res Public Health 2021; 19 (1): 328. DOI: 10.3390/ijerph19010328. PMID: 35010587; PMCID: PMC8751073. 
25. Ricci E, Al Beitawi S, Cipriani S et al. Semen quality and alcohol intake: a systematic review and meta-analysis. Reprod Biomed Online 2017; 34 (1): 38–47. DOI: 10.1016/j.rbmo.2016.09.012 
26. Leisegang K, Dutta S. Do lifestyle practices impede male fertility? Andrologia 2021; 53 (1): e13595. DOI: 10.1111/and.1359 
27. Rao W, Li Y, Li N et al. The association between caffeine and alcohol consumption and IVF/ICSI outcomes: A systematic review and doseresponse meta-analysis. Acta Obstet Gynecol Scand 2022; 101 (12): 1351–63. DOI: 10.1111/aogs.14464 
28. Rossi BV, Berry KF, Hornstein MD et al. Effect of alcohol consumption on in vitro fertilization. Obstet Gynecol 2011; 117 (1): 136–42. DOI: 10.1097/AOG.0b013e31820090e1. PMID: 21173655; PMCID: PMC4487775. 
29. Sermondade N, Elloumi H, Berthaut I et al. Progressive alcohol-induced sperm alterations leading to spermatogenic arrest, which was reversed after alcohol withdrawal. Reprod Biomed Online 2010; 20 (3): 324–7. DOI: 10.1016/j.rbmo.2009.12.003. PMID: 20117050. 
30. Hajizadeh Maleki B, Tartibian B, Chehrazi M. Effects of Aerobic, Resistance, and Combined Exercise on Markers of Male Reproduction in Healthy Human Subjects: A Randomized Controlled Trial. J Strength

For citation:Korneyev I.A. A personalized approach to antioxidant therapy for treatment of men in infertile couples. Clinical review for general practice. 2023; 4 (4): 82–88. DOI: 10.47407/kr2023.4.4.00260


All accepted articles publish licensed under a Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

  • About
  • Editorial board
  • Ethics
  • For authors
  • Author fees
  • Peer review
  • Contacts

oa
crossref
анри


  Indexing

doaj
elibrary

Address of the Editorial Office:

127055, Moscow, s/m 37

Correspondence address:

115054, Moscow, Zhukov passage, 19, fl. 2, room XI


Managing Editor:

+7 (495) 926-29-83

id@con-med.ru