Hydrolyzed marine collagen in complex therapy of degenerative-dystrophic changes in the mustocular system

Dmitry I. Trukhan , Darya S. Ivanova

For citation:

Abstract

Degenerative-dystrophic changes in the musculoskeletal system of various localizations are one of the most common reasons for patients to turn not only to a rheumatologist, but also to a neurologist and first-contact doctors (therapist and general practitioner) who provide primary health care. Medicines that modify the symptoms of degenerative-dystrophic changes in the musculoskeletal system are divided into “fast-acting” (analgesics, NSAIDs, tramadol) and “slow-acting” (chondroprotectors). When considering “slow-acting” drugs, many publications are devoted to the natural components of the cartilage intercellular substance – glucosamine and chondroitin sulfate, while much less attention is paid to the importance of collagen. In articular cartilage, collagens provide most of the biomechanical properties of the extracellular matrix necessary for its function. Collagen hydrolysates have demonstrated positive results in clinical trials related to joint health, such as reducing joint pain, increasing mobility, and improving joint structure. Marine collagen is the closest in molecular structure to human collagen fibers. Its main characteristics include high biological activity and biocompatibility, as well as low antigenicity. The possible effects of vitamin C, vitamin D3, zinc and calcium in the complex treatment of degenerative-dystrophic changes in the musculoskeletal system are considered. A biological supplement containing vitamins, microelements and hydrolyzed marine collagen Promerim® optimizes the prevention and treatment of patients with degenerative changes in the musculoskeletal system.
Key words: degenerative-dystrophic changes in the musculoskeletal system, osteoarthritis, treatment, prevention, collagen, Promerim® hydrolylated marine collagen, vitamin C, vitamin D3, Zinc, Calcium.

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For citation:Trukhan D.I., Ivanova D.S. Hydrolyzed marine collagen in complex therapy of degenerative-dystrophic changes in the mustocular system. Clinical review for general practice. 2023; 4 (8): 60–67 (In Russ.). DOI: 10.47407/kr2023.4.8.00332

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Clinical review for general practice