Abstract
Objective. To present a clinical observation of a patient with a moderate course of coronavirus infection and COVID-19-associated liver damage.
Materials and methods. A clinical case of patient P., 56 years old, with a diagnosis of coronavirus infection COVID-19 and changes in liver function of a mixed nature, regarded as COVID-19-associated liver damage, treated with ursodeoxycholic acid (UDCA), is described. A dynamic assessment of physical data, general and biochemical blood tests, ultrasound of the abdominal cavity was performed after two months.
Results. Against the background of ongoing therapy with the use of ursodeoxycholic acid, there was an improvement in the patient's general well-being, positive laboratory dynamics of alanine transferase (ALT), aspartate transferase (AST), and total bilirubin. Ultrasound of the abdominal cavity revealed normalization sizes of the right and left lobes of the liver, compared with the initial data.
Conclusion. The use of ursodesoxycholic acid in a patient with COVID-19-associated liver damage was accompanied by positive dynamics in the form of normalization of hepatic enzymes and improvement of general condition. More research is needed to investigate the mechanism of action of UDCA in patients with COVID-19 and liver pathology.
Keywords: COVID-19 infection, liver pathology, UDCA.
Materials and methods. A clinical case of patient P., 56 years old, with a diagnosis of coronavirus infection COVID-19 and changes in liver function of a mixed nature, regarded as COVID-19-associated liver damage, treated with ursodeoxycholic acid (UDCA), is described. A dynamic assessment of physical data, general and biochemical blood tests, ultrasound of the abdominal cavity was performed after two months.
Results. Against the background of ongoing therapy with the use of ursodeoxycholic acid, there was an improvement in the patient's general well-being, positive laboratory dynamics of alanine transferase (ALT), aspartate transferase (AST), and total bilirubin. Ultrasound of the abdominal cavity revealed normalization sizes of the right and left lobes of the liver, compared with the initial data.
Conclusion. The use of ursodesoxycholic acid in a patient with COVID-19-associated liver damage was accompanied by positive dynamics in the form of normalization of hepatic enzymes and improvement of general condition. More research is needed to investigate the mechanism of action of UDCA in patients with COVID-19 and liver pathology.
Keywords: COVID-19 infection, liver pathology, UDCA.
For citation:Safonova K.A., Dekhnich N.N., Abramenkova N.Yu., Chestnykh S.V., Ilyin D.Yu., Punin A.A. Clinical case: liver damage in a patient with coronavirus disease. Clinical review for general practice. 2024; 5 (6): 21–25 (In Russ.). DOI: 10.47407/kr2024.5.6.00430
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