Prevalence of cognitive impairment among patients with multiple sclerosis

Olga V. Kurushina , Rubiella Sarai Rohas

For citation:

Abstract

Multiple sclerosis (MS) is a chronic autoimmune disorder that manifests itself in progressive neurodegeneration causing a broad spectrum of cognitive deficits in the patients. Cognitive impairment being an essential component of the clinical picture of the disease come in a variety of manifestations and significantly lower the MS patients’ quality of life. This paper reports contemporary views on the prevalence and pathogenesis of cognitive impairment; the data of original studies involving patients with multiple sclerosis are provided.
Keywords: multiple sclerosis, cognitive impairment, speech.

References

1. Бойко А.Н., Бахтиярова К.З., Шерман М.А. и др. Результаты иссле-

дования качества жизни у больных с высокоактивным рассеянным

склерозом в России. Неврология, нейропсихиатрия, психосома-

тика. 2022;14(S1):9-15.

Boyko A.N., Bakhtiyarova K.Z., Sherman M.A. et al. The results of a

study of the quality of life in patients with highly active multiple sclero-

sis in Russia. Neurology, neuropsychiatry, psychosomatics.

2022;14(S1):9-15 (in Russian).

2. Бойко А.Н., Петров С.В., Нестерова В.А., Гусев Е.И. Механизмы

развития нейродегенеративного процесса при рассеянном склеро-

зе – нейропротективное влияние препаратов β-интерферона сего-

дня и нейротрофические факторы завтра. Журнал неврологии и

психиатрии им. С.С. Корсакова. Спецвыпуск «Рассеянный скле-

роз». 2003;(2):83-90.

Boyko A.N., Petrov S.V., Nesterova V.A., Gusev E.I. Mechanisms of de-

velopment of the neurodegenerative process in multiple sclerosis –

neuroprotective effect of beta-interferon preparations today and neu-

rotrophic factors tomorrow. Journal of Neurology and Psychiatry

named after S.S. Korsakov. Special issue "Multiple sclerosis".

2003;(2):83-90 (in Russian).

3. Алексеева Т.А., Бойко А.Н., Гусев Е.И. Спектр нейропсихологиче-

ских изменений при рассеянном склерозе. Журнал неврологии и

психиатрии им. С. С. Корсакова. 2000;(11):15-20.

Alekseeva T.A., Boyko A.N., Gusev E.I. Spectrum of neuropsycholog-

ical changes in multiple sclerosis. Journal of Neurology and

Psychiatry named after S.S. Korsakov. 2000;(11):15-20

(in Russian).

4. Сиверцева С.А., Лащ Н.Ю., Зотова А.В. и др. Роль цереброваску-

лярных заболеваний в прогрессировании рассеянного склероза.

Журнал неврологии и психиатрии им. С.С. Корсакова.

2024;124(5):53-7.

Sivertseva S.A., Lasch N.Yu., Zotova A.V. et al. The role of cerebrovas-

cular diseases in the progression of multiple sclerosis. Journal of Neu-

rology and Psychiatry named after S.S. Korsakov. 2024;124(5):53-7

(in Russian).

5. Алексеева Т.Г., Бойко А.Н., Батышева Т.Т. и др. Когнитивные и

эмоционально-личностные изменения при рассеянном склерозе.

Руководство для врачей: Рассеянный склероз и другие демиелини-

зирующие заболевания. М.: Миклош, 2004.

Alekseeva T.G., Boyko A.N., Batysheva T.T. et al. Cognitive and emo-

tional-personal changes in multiple sclerosis. A guide for doctors: Mul-

tiple sclerosis and other demyelinating diseases. Moscow: Miklos, 2004

(in Russian).

6. Vukusi S, Confavreux C. [Multiple sclerosis and pregnancy]. Revue

Neulogique [Internet]. 2006 [cited 2022 Mar 27];162:299-309. Avail-

able in: https://pubmed.ncbi.nlm.nih.gov/16585885/

7. Reddy H, Narayanan S, Arnoutelis R et al. Evidence of adaptive func-

tional changes in the cerebral cortex with multiple sclerosis axonal in-

jury. Brain elfkbnm. 2000;123:2314-20.

8. Jacobsen C, Hagemeier J, Myhr KM et al. Cerebral atrophy and disabil-

ity progression in patients with multiple sclerosis: a 10-year follow-up

study. Journal of Neurology, Neurosurgery and Psychiatry [Internet].

2014 Oct 1 [cited 2022 Feb 28];85(10):1109-15. Available in: https://jn-

np.bmj.com/content/85/10/1109

9. Calabrese M, Agosta F, Rinaldi F et al. Cortical lesions and atrophy as-

sociated with cognitive impairment in relapsing-remitting multiple

sclerosis. Arch Neurol [Internet] 2009 Sep [cited 2022 Feb

28];66(9):1144-50. Available in: https://pubmed.ncbi.nlm.

nih.gov/19752305/

10. Beatty WW et al. Frontal lobe dysfunction and memory impairment in

patients with chronic progressive multiple sclerosis. Brain Cogn

1989;(11):73-86.

11. Beatty WW, Wibanks SL et al. Memory disturbance in multiple sclero-

sis: reconsideration of patients of performance on the selective remind-

ing test. J Clin Exp Neuropsychol 1996;318(1):56-62.

12. Rao SM, Glatt S et al. Chronic progressive multiple sclerosis relation-

ship between cerebral ventricular size and neuropsychological impair-

ment. Arch Neurol 1985;42:678-82.

13. Vicens A, Iriarte J, de-Castro-P et al. Cognitive functions in multiple

sclerosis. Neurologia 1992;(7):171-5.

14. Duan Y, Liu Y, Liang P et al. Comparison of gray matter atrophy among

patients with neuromyelitis optica and multiple sclerosis: a voxel-based

morphometry study. Eur J Radiol [Internet] 2012 Feb [cited 2022 Mar

29];81(2). Available in: https://pubmed.ncbi.nlm.nih.gov/21316170/

15. Geurts JJ, Barkhof F. Pathology of gray matter in multiple sclerosis.

Lancet Neurol [Internet] 2008 Sep [cited 2022 Mar 29];7(9):841-51.

Available in: https://pubmed.ncbi.nlm.nih.gov/18703006/

16. Shu N, Duan Y, Xia M et al. Interrupted topological organization of

structural and functional brain connectomes in clinically isolated syn-

drome and multiple sclerosis. Scientific Reports 2016 6:1 [Internet]

2016 Jul 12 [cited 2022 Mar 29];6(1):1-11. Available in:

https://www.nature.com/articles/srep29383

17. Anne G. Osborn, Gary L. Hedlund KLS. Osborn's Brain imaging,

pathology, and anatomy, Second edition (2018, Elsevier). Physical re-

view B. 2018;123–54.

18. Puppo C. Introduction Cerebrovascular reactivity. Hospital de Clínicas

Uruguay [Internet] 2016 [cited 2022 Mar 29]; Available in:

https://cdn1.redemc.net/campus/wp-content/uploads/2016/08/PCR-

Puppo-autorregulaci%C3%B3n-cerebral-REV.pdf

19. Sperling RA, Guttmann CRG, Hohol MJ et al. Regional magnetic reso-

nance injury burden and cognitive function in multiple sclerosis: a lon-

gitudinal study. Arch Neurol [Internet] 2001 [cited 2022 Mar

29];58(1):115-21. Available in: https://pubmed.ncbi.nlm.nih.gov/

11176944/

20. Sepulcre J, Masdeu JC, Goñi J et al. Fatigue in multiple sclerosis is as-

sociated with disruption of the frontal and parietal pathways. Mult

Scler [Internet] 2009 [cited 2022 Mar 29];15(3):337-44. Available in:

https://pubmed.ncbi.nlm.nih.gov/18987107/

21. Алексеева Т.Г., Ениколопова Е.В., Садальская Е.В. и др. Комплекс-

ный подход к оценке когнитивной и эмоционально-личностной

сфер у больных рассеянным склерозом. Журнал неврологии и пси-

хиатрии им. С.С. Корсакова. 2002. Спецвыпуск «Рассеянный

склероз»:20-6.

Alekseeva T.G., Enikolopova E.V., Sadalskaya E.V. et al. An integrated

approach to the assessment of cognitive and emotional-personal

spheres in patients with multiple sclerosis. Journal of Neurology and

Psychiatry named after S.S. Korsakov. 2002. Special issue "Multiple

sclerosis":20-6 (in Russian).

22. Corvette M, Kincade JM, Ollinger JM et al. Voluntary guidance is dis-

sociated from target detection in the human posterior parietal cortex.

Nat Neurosci [Internet] 2000 Mar [cited 2022 Mar 29];3(3):292-7.

Available in: https://pubmed.ncbi.nlm.nih.gov/10700263/

For citation:Kurushina O.V., Rohas R.S. Prevalence of cognitive impairment among patients with multiple sclerosis. Clinical review for general practice. 2024; 5 (8): 102–106 (In Russ.). DOI: 10.47407/kr2024.5.8.00467

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Clinical review for general practice