Clinical review for general practice

ISSN (Print) 2713-2552
ISSN (Online) 2782-5671
  • Home
  • about
  • archives
  • contacts
left
FULLSCREEN > Archive > 2024 > Vol 5, №1 (2024) > Fixed-dose combination drugs containing vitamins: two-step therapy of pain syndrome

Fixed-dose combination drugs containing vitamins: two-step therapy of pain syndrome

Olga A. Shavlovskaya

For citation:


  • Abstract
  • About the Author
  • References

Abstract

Simple analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), muscular and epidural blocks are most often prescribed to relieve acute pain. However, the use of a number of drugs is associated with the development of unwanted side effects. Furthermore, in some cases the need for both symptomatic and pathogenetic therapy necessitates the prescription of combination treatment involving drugs that exert metabolic effects. The paper discusses the role of metabolic therapy in patients with pain syndrome exemplified by the drugs containing B vitamins. Emphasis is placed on the two-step therapy of pain syndrome.
Keywords: pain syndrome, low back pain, diabetic polyneuropathy, metabolic therapy, B vitamins.

About the Author

Olga A. Shavlovskaya 1

1 International University of Restorative Medicine, Moscow, Russia

References

1. Грацианская А.Н. Нейромультивит в лечении полинейропатии. Фарматека. 2007;15:37-41.
Grazianskaya A.N. Neuromultivitis in the treatment of polyneuropathy. Pharmateca. 2007;15:37-41 (in Russian).
2. Mibielli MA, Nunes CP, Scussel Jr AB et al. Symptomatic improvement in an acute, non-traumatic spine pain model with a combination of uridine triphosphate, cytidine monophosphate, and hydroxocobalamin. Pain Studies and Treatment. 2014;2(1):6-10.
3. Курушина О.В., Барулин А.Е. Полинейропатии при соматических заболеваниях: роль невролога в диагностике и лечении. Российский медицинский журнал. 2013;36:1843.
Kurushina O.V., Barulin A.E. Polyneuropathies in somatic diseases: the role of a neurologist in diagnosis and treatment. Russian Medical Journal. 2013;36:1843 (in Russian).
4. Аметов А.С., Солуянова Т.Н. Роль витаминов группы B в лечении диабетической полинейропатии. Медицинский совет. 2010;7:
18-20.
Ametov A.S., Soluyanova T.N. The role of B vitamins in the treatment of diabetic polyneuropathy. Medical advice. 2010;7:18-20 (in Russian).
5. Bruggemann G, Koehler CO, Koch EMW. Ergebnisse einer Doppelblindprüfung Diclofenac + Vitamin B1, B6, B12 versus Diclofenac bei Patienten mit akuten Beschwerden im Lendenwirbelsäulenbereich. Klin Wochenschr. 1990;68:116-20.
6. Kuhlwein A, Meyer HJ, Koehler CO. Einsparung von Diclofenac durch B-Vitamine: Ergebnisse einer randomisierten Doppelblindprüfung mit reduzierten Tagesdosierungen von Diclofenac (75 mg Diclofenac versus 75 mg Diclofenac plus B-Vitamine) bei akuten Lendenwirbelsäulensyndromen. Klin Wochenschr. 1990;68:107-15.
7. Lettko M, Schwieger G, Pudel V. Ergebnisseeiner Doppelblind studie, Neurofenacgegen Diclofenac, zum Nachweis der additiven Wirksamkeit der B-Vitamine. Rheuma, Schmerz & Enzundung. 1986;8:
22-30.
8. Kopruszinski CM, Reis RC, Chichorro JG. B vitamins relieve neuropathic pain behaviors induced by infraorbital nerve constriction in rats. LifeSci. 2012;91(23-24):1187-95.
9. Вялов С.С. Пациенты с поясничной невралгией: особенности терапии поясничного синдрома. Справочник поликлинического врача. 2013;12:16-22.
Vyalov S.S. Patients with lumbar neuralgia: features of lumbar syndrome therapy. The directory of the polyclinic doctor. 2013;12:16-22 (in Russian).
10. Умарова Х.Я. Хронические болевые синдромы – применение нейротропных витаминов. Справочник поликлинического врача. 2013;10:48-50.
Umarova H.Ya. Chronic pain syndromes – the use of neurotropic vitamins. The directory of the polyclinic doctor. 2013;10:48-50 (in Russian).
11. Шавловская О.А. Использование витаминов группы В в комплексной терапии болевых синдромов. Журнал неврологии и психиатрии. 2017;9:118-23.
Shavlovskaya O.A. The use of B vitamins in the complex therapy of pain syndromes. Journal of Neurology and Psychiatry. 2017;9:118-23 (in Russian).
12. Шавловская О.А. Полинейропатия: современные аспекты метаболической терапии. Медицинский совет. 2013;12:38-42.
Shavlovskaya O.A. Polyneuropathy: modern aspects of metabolic therapy. Medical advice. 2013;12:38-42 (in Russian).
13. Левин О.С., Мосейкин И.А. Комплекс витаминов группы В (Мильгамма) в лечении дискогенной пояснично-крестцовой радикулопатии. Международный неврологический журнал. 2011;5(43):40-6.
Levin O.S., Moseikin I.A. Vitamin B complex (Milgamma) in the treatment of discogenic lumbosacral radiculopathy. International Journal of Neurology. 2011;5(43):40-6 (in Russian).
14. Вознюк К.О., Чурюканов М.В., Бахтадзе М.А. Сравнение болезненности инъекций витаминов группы B, содержащих и не содержащих лидокаин. Российский журнал боли. 2020;18(3):20-4. DOI: 10.17116/pain20201803120
Voznyuk K.O., Churyukanov M.V., Bakhtadze M.A. Comparison of the painfulness of injections of B vitamins containing and not containing lidocaine. The Russian Journal of Pain. 2020;18(3):20-4. DOI: 10.17116/pain20201803120 (in Russian).
15. Манушарова Р.А., Черкезов Д.И. Применение Нейромультивита при диабетической периферической полинейропатии. Медицинский совет. 2011;1-2:68-71.
Manusharova R.A., Cherkezov D.I. The use of Neuromultivitis in diabetic peripheral polyneuropathy. Medical advice. 2011;1-2:68-71 (in Russian).
16. Токмакова А.Ю., Анциферов М.Б. Возможности использования Нейромультивита в комплексной терапии полинейропатии у больных сахарным диабетом. Сахарный диабет. 2001;11(2):33-5.
Tokmakova A.Yu., Antsiferov M.B. The possibilities of using Neuromultivitis in the complex therapy of polyneuropathy in patients with diabetes mellitus. Diabetes mellitus. 2001;11(2):33-5. (in Russian).
17. Mibielli MA, Geller M, Cohen JC et al. Diclofenac plus B vitamins versus diclofenac monotherapy in lumbago: the DOLOR study. Curr Med Res Opin. 2009;25(11):2589-99.
18. Ponce-Monter HA, Ortiz MI, Garza-Hernández AF et al. Effect of diclofenac with B vitamins on the treatment of acute pain originated by lower-limb fracture and surgery. Pain Res Treat. 2012;2012:104782.
19. Geller M, Mibielli MA, Nunes CP et al. Impact of low back pain on Quality of Life: assessment by patient functionality questionnaire and treatment results using a combination of Diclofenac plus B vitamins or Diclofenac monotherapy. Int J Clin Med. 2016;7:113-9.
20. Mauro Geller, Marco Antonio Mibielli, Carlos Pereira Nunesetal. Comparison of the action of diclofenac alone versus diclofenac plus B vitamins on mobility in patients with low back pain. Journal of drug assessment. 2016;5(1):1-3.
21. Хабиров Ф.А., Хайбуллин Т.И., Гранатов Е.В. Эффективность и безопасность нейромультивита при вертеброгенных радикулопатиях. Журнал неврологии и психиатрии. 2017;10:38-43.
Khabirov F.A., Khaibullin T.I., Granatov E.V. Efficacy and safety of neuromultivitis in vertebrogenic radiculopathies. Journal of Neurology and Psychiatry. 2017;10:38-43 (in Russian).
22. Calderon-Ospina C-A et al. Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis. Pain Medicine. 2020;21(4):766-81.
23. Инструкция по медицинскому применению препарата Нейромультивит®.
Instructions for the medical use of the drug Neuromultivit® (in Russian).

For citation:Shavlovskaya O.A. Fixed-dose combination drugs containing vitamins: two-step therapy of pain syndrome. Clinical review for general practice. 2024; 5 (1): 65–70 (In Russ.). DOI: 10.47407/kr2023.5.1.00361


All accepted articles publish licensed under a Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

  • About
  • Editorial board
  • Ethics
  • For authors
  • Author fees
  • Peer review
  • Contacts

oa
crossref
анри


  Indexing

doaj
elibrary

Address of the Editorial Office:

127055, Moscow, s/m 37

Correspondence address:

115054, Moscow, Zhukov passage, 19, fl. 2, room XI


Managing Editor:

+7 (495) 926-29-83

id@con-med.ru