Modern respiratory epithelium protection mechanisms

Lubov A. Ponomareva , Igor S. Zubarev , Svetlana A. Berns , Alina A. Chinova , Elena N. Popova

For citation:

Abstract

N-acetylcysteine (Fluimucil) is characterized by high antioxidant potential due to direct effect on both free radicals through inhibition of free radical reactions, including those related to the mechanisms underlying the iron-dependent cell death (ferroptosis), and the synthesis of the antioxidant molecules constituting the antioxidant protection system. The review is focused on the N-acetylcysteine involvement in the development of antioxidant protection and on the use of high doses of N-acetylcysteine in combination with thiamphenicol for treatment of bacterial infections.
Keywords: respiratory epithelium, inflammatory pulmonary diseases, bacterial infections, N-acetylcysteine.

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For citation:Ponomareva L.A., Zubarev I.S., Berns S.A., Chinova A.A., Popova E.N. Modern respiratory epithelium protection mechanisms. Clinical review for general practice. 2024; 5 (11): 76–82 (In Russ.). DOI: 10.47407/kr2024.5.11.00520

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Clinical review for general practice