Clinical review for general practice

ISSN (Print) 2713-2552
ISSN (Online) 2782-5671
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FULLSCREEN > Archive > 2024 > Vol 5, №4 (2024) > The experience of successful use of dapagliflozin to manage adverse effects due to uncontrolled and long-term use of torasemide in a patient with type 2 diabetes mellitus with comorbid obesity. A clinical example Портал CON-MED.RU: https://con-med.ru/mag

The experience of successful use of dapagliflozin to manage adverse effects due to uncontrolled and long-term use of torasemide in a patient with type 2 diabetes mellitus with comorbid obesity. A clinical example Портал CON-MED.RU: https://con-med.ru/mag

Vitaly V. Gorban , Ivan A. Gerasimenko

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Abstract

This article provides an example of a smooth and successful withdrawal of long-term and unjustified use of a diuretic (torasemide) in patients with type 2 diabetes mellitus with comorbid obesity by prescribing sodium-glucose cotransporter type 2 inhibitor (dapagliflozin).
Keywords: dapagliflozin, type 2 diabetes mellitus, obesity, torasemide.

About the Author

Vitaly V. Gorban 1 , Ivan A. Gerasimenko 2

1 Kuban State Medical University, Krasnodar, Russia

2 Kuban State Medical University, Krasnodar, Russia; Clinic Preobrazhenskaya, Krasnodar, Russia

References

1. Mascolo M, Chu ES, Mehler PS. Abuse and clinical value of diuretics in eating disorders therapeutic applications. Int J Eat Disord 2011; 44(3):200-2. DOI: 10.1002/eat.20814
2. Solomon SD, McMurray JJV, Claggett B et al. DELIVER Trial Committees and Investigators. Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction. N Engl J Med 2022;387(12): 1089-98. DOI: 10.1056/NEJMoa2206286
3. Wilcox CS, Shen W, Boulton DW et al. Interaction Between the Sodium-Glucose-Linked Transporter 2 Inhibitor Dapagliflozin and the Loop Diuretic Bumetanide in Normal Human Subjects. J Am Heart Assoc 2018; 7(4):e007046. DOI: 10.1161/JAHA.117.007046
4. McMurray JJV, Solomon SD, Inzucchi SE et al. DAPA-HF Trial Committees and Investigators. Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction. N Engl J Med 2019;381(21):1995-2008. DOI: 10.1056/NEJMoa1911303
5. Cadwallader AB., de la Torre X, Tieri A, Botrè F. The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: pharmacology, toxicology and analysis. Br J Pharmacol 2010;161(1):1-16. DOI: 10.1111/j.1476-5381.2010.00789.x
6. Grodin JL, Tang WHW. Sodium-Glucose Cotransporter-2 Inhibitors and Loop Diuretics for Heart Failure: Priming the Natriuretic and Metabolic Reserve of the Kidney. Circulation 2020;142(11):1055-8. DOI: 10.1161/CIRCULATIONAHA.120.048057. Epub 2020 Sep 14. PMID: 32924569; PMCID: PMC7495489.
7. Прокопенко Е., Будникова Н. Злоупотребление диуретиками: взгляд нефролога. Врач. 2012;23(6):12-6.
Prokopenko E, Budnikova N. The abuse of diuretics: the look of nephrologist. Doctor. 2012;23(6):12-6 (in Russian).

For citation:Gorban V.V., Gerasimenko I.A. The experience of successful use of dapagliflozin to manage adverse effects due to uncontrolled and long-term use of torasemide in a patient with type 2 diabetes mellitus with comorbid obesity. A clinical example. Clinical review for general practice. 2024; 5 (4): 6–8 (In Russ.). DOI: 10.47407/kr2024.5.4.00413


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