Clinical review for general practice

ISSN (Print) 2713-2552
ISSN (Online) 2782-5671
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FULLSCREEN > Archive > 2024 > Vol 5, №7 (2024) > Effects of Radiation on Physiological Hormones and Immune Proteins Associated with Cancer Antegens

Effects of Radiation on Physiological Hormones and Immune Proteins Associated with Cancer Antegens

Ahmed R. AL Moustafa , Zahra I. Dallalbashi

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  • Abstract
  • About the Author
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Abstract

Background. Radiation is an environmental factor that can lead to changes in the level of hormones in the body and to variables in the function of the body. The study examined the impact of radiation on certain hormones and vital indicators for understanding its physiological effects on human health. 
Methodology. The study was carried out on two groups of non-smokers, non-alcoholics, and peaceful people with chronic diseases, and each group (40 blood samples) aged 20–6 years and 3–5 ml of blood were collected from each person. The decomposed samples were excluded to avoid erroneous results: the two groups were a non-irradiated group and an irradiated group. The level of prolactin hormone, cortisol hormone, colon cancer protein (CEA), and pancreatic cancer protein(CA19-9) was measured in both groups using MINDRY precision laboratory techniques and devices.
Results. Prolactin prolactin results showed a pronounced significant decrease in the irradiated group with the non-irradiated group. Cortisol: The results of the cortisol study showed a clear increase in people exposed to radiation compared to people who were not exposed to radiation. The results of colon cancer protein (CEA) and pancreatic cancer protein (CA19-9) showed a significant and clear increase in people exposed to radiation compared to people not exposed to radiation.
Conclusion. This study showed that radiation exposure negatively affects hormone levels and vital disease indicators in the human body. This study highlights the importance of systematic monitoring and complete preventive health care in individuals exposed to radiation to assess health risks.
Keywords: radiation, cancer, CEA, CA19-9, prolactin, cortisol.

About the Author

Ahmed R. AL Moustafa 1 , Zahra I. Dallalbashi 2

1 University of Mosul, College of Environmental Sciences, Department of Environmental Sciences, Mosul, Iraq; Northern technical university Technical institute Hawija, Hawija Iraq

2 University of Mosul, College of Environmental Sciences, Department of Environmental Sciences, Mosul, Iraq

References

1. Anderson J, Brown T, Davis L. Radiation exposure and cortisol levels: understanding the biological stress response. J Radiat Biol. 2019;45(3):210-20.
2. Clark N, Thompson D. Immune system alterations due to radiation. 
J Immunol. 2017;34(3):213-21.
3. Gold DV, Modrak DE, Ying Z et al. New MAb PR1A3 and CA19-9 antigen in diagnosis of pancreatic cancer. Clin Cancer Res. 2006;12(14):4428-34.
4. Hall EJ, Giaccia AJ. Radiobiology for the Radiologist. Philadelphia: Lippincott Williams & Wilkins; 2006.
5. Hammarström S. The carcinoembryonic antigen (CEA) family: structures, suggested functions, and expression in normal and malignant tissues. Semin Cancer Biol. 1999;9(2):67-81.
6. Jones M, Brown T. Oxidative stress and hormonal changes induced by radiation. J Radiat Res. 2015;30(2):123-32.
7. Kim HJ, Lee KS, Park SH. Impact of radiation on pancreatic cancer antigen 19-9 levels. Cancer Biomark. 2017;18(1):67-74.
8. Kim J, Lee S, Park C et al. Disruption of the HPA axis by ionizing radiation. Endocrinology. 2015;156(3):1101-10.
9.  Life of Zaher. Hormones that cause infertility in women. Alexandria: Ma'arif facility, 1990.
10. Little MP. Risks associated with ionizing radiation. Br Med Bull. 2003;68(1):259-75.
11. Makin G. Clinical implications of radiation damage to the HPA axis. Clin Endocrinol (Oxf). 2002;57(1):17-24.
12. Miller A, White R, Turner L et al. Long-term effects of occupational radiation exposure on cortisol levels. Occup Health Saf. 2016;45(4):567-74.
13. Miller LE, Brown TR, Davis MJ. Radiation exposure and colorectal cancer antigen levels. J Oncol Res. 2015;12(3):225-33.
14. Ogilvy-Stuart AL, Shalet SM. Effect of radiation on the human reproductive system. Environ Health Perspect. 1993;101 (Suppl. 2):109-16.
15. Park Y, Kim H, Han S et al. Changes in serum tumor markers (CEA, CA19-9) during concurrent chemoradiotherapy in rectal cancer patients. Radiat Oncol J. 2011;29(2):113-20.
16. Smith J, Doe A, Johnson L. The impact of radiation exposure on prolactin levels: a review. Int J Endocr Sci. 2018;23(4):567-79.
17. Taylor M, Smith K. Immune system and hormonal changes post radiation exposure. J Immunol Stud. 2015;27(4):345-55.
18. Tijani H, Abdullah N, Yuzir A. Enhancing methane production of palm oil mill effluent using two-stage domesticated shear-loop anaerobic contact stabilization system. J Clean Prod. 2018;200:971-81.
19. White H, Parker R. Hormonal responses to radiation exposure. Endocr Res J. 2017;29(2):130-40.
20. Williams K, Green R, Harris P. Hormonal disruptions following radiation exposure. Endocrinol Today. 2016;18(1):45-52.
21. Yamazaki S, Tanaka H, Nakata M et al. Radiation-induced changes in cortisol levels in mice. J Radiat Res. 2018;59(2):123-30.
22. Yang Y, Muzny DM, Reid JG et al. Clinical whole-exome sequencing for the diagnosis of Mendelian disorders. N Engl J Med. 2013;369(16):1502-11.


For citation:Al Moustafa A.R., Dallalbashi Z.I. Effects of Radiation on Physiological Hormones and Immune Proteins Associated with Cancer Antegens. Clinical review for general practice. 2024; 5 (7): 46–50. DOI: 10.47407/kr2024.5.7.00447


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