Clinical review for general practice

ISSN (Print) 2713-2552
ISSN (Online) 2782-5671
  • Home
  • about
  • archives
  • contacts
left
FULLSCREEN > Archive > 2024 > Vol 5, №8 (2024) > Isolated trochlear nerve palsy: case report and modern considerations

Isolated trochlear nerve palsy: case report and modern considerations

Anna N. Belova , Gennadii E. Sheiko , Vera N. Grigoryeva , Evgenij A. Kliuev , Marina V. Rasteryaeva

For citation:


  • Abstract
  • About the Author
  • References

Abstract

Neurologically isolated trochlear nerve (TN) injury is uncommon. We describe the case of acute vertical diplopia development in a 64-year-old man who considered himself healthy. The cause of diplopia was neuropathy of TN. The diagnostic search gave reason to assume that TN damage was associated with microangiopathy caused by arterial hypertension and dyslipidemia newly diagnosed in the patient. A diagnostic algorithm for acute vertical diplopia and the range of diseases for differentiation with isolated TN neuropathy are discussed, as well as the prognosis and patient’s management. The association of isolated TN neuropathy with migraine and the risk of ischemic stroke is considered.
Keywords: fourth cranial (trochlear) nerve, isolated palsy, diplopia.

About the Author

Anna N. Belova 1 , Gennadii E. Sheiko 1 , Vera N. Grigoryeva 1 , Evgenij A. Kliuev 1 , Marina V. Rasteryaeva 1

1 Privolzhsky Research Medical University, Nizhny Novgorod, Russia

References

1. Kung NH, Van Stavern GP. Isolated Ocular Motor Nerve Palsies. Semin Neurol 2015;35(5):539-48. DOI: 10.1055/s-0035-1563568
2. Tamhankar MA, Biousse V, Ying GS et al. Isolated third, fourth, and sixth cranial nerve palsies from presumed microvascular versus other causes: a prospective study. Ophthalmology 2013;120(11):2264-9. DOI: 10.1016/ j.ophtha.2013.04.009
3. Wong AM. Understanding skew deviation and a new clinical test to differentiate it from trochlear nerve palsy. J AAPOS 2010;14(1):61-7. DOI: 10.1016/j.jaapos.2009.11.019
4. Lee AG, Anne HL, Beaver HA et al. A guide to the evaluation of fourth cranial nerve palsies. Strabismus 1998;6(4):191-200. DOI: 10.1076/ stra.6.4.191.620
5. Morillon P, Bremner F. Trochlear nerve palsy. Br J Hosp Med 2017;78(3):C38-C40. DOI: 10.12968/hmed.2017.78.3.C38
6. Hoi CP, Chen YT, Fuh JL et al. Increased Risk of Stroke in Patients with Isolated Third, Fourth, or Sixth Cranial Nerve Palsies: A Nationwide Cohort Study. Cerebrovasc Dis 2016;41(5-6):273-82. DOI: 10.1159/ 000444128
7. Jung EH, Kim SJ, Lee JY, Cho BJ. The incidence and presumed aetiologies of fourth cranial nerve palsy in Korea: a 10-year nationwide cohort study. Eye (Lond) 2021;35(11):3012-9. DOI: 10.1038/s41433-020-01374-0
8. Chen WC, Li YS, Huang P. Isolated trochlear palsy as the only presentation of midbrain infarction: a case report. J Int Med Res 2021;49(4): 3000605211008292. DOI: 10.1177/03000605211008292
9. Dosunmu EO, Hatt SR, Leske DA et al. Incidence and Etiology of Presumed Fourth Cranial Nerve Palsy: A Population-based Study. Am J Ophthalmol 2018;185:110-4. DOI: 10.1016/j.ajo.2017.10.019
10. Common Neuro-Ophthalmic Pitfalls: Case-Based Teaching. Edited by V.A. Purvin, A. Kawasaki. Cambridge University Press, 2009. DOI: 10.1017/CBO9780511575808
11. Engel JM. Treatment and diagnosis of congenital fourth nerve palsies: an update. Curr Opin Ophthalmol 2015;26(5):353-6. DOI: 10.1097/ICU. 0000000000000179
12. Parks MM. Isolated cyclovertical muscle palsy. Arch Ophthalmol 1958;60(6):1027-35. DOI: 10.1001/archopht.1958.00940081047008
13. Brazis PW. Palsies of the Trochlear Nerve: Diagnosis and Localization–Recent Concepts. Mayo Clin Proc 1993;68(5):501-9. DOI: 10.1016/S0025-6196(12)60201-8
14. Manchandia AM, Demer JL. Sensitivity of the three-step test in diagnosis of superior oblique palsy. J AAPOS 2014;18(6):567-71. DOI: 10.1016/j.jaapos.2014.08.007
15. García-Zamora M, Sánchez-Tocino H, Villanueva-Gómez A et al. Isolated Fourth Nerve Palsy in Tuberculous Meningitis. Neuroophthalmology 2016;40(1):40-3. DOI: 10.3109/01658107.2015.1116590
16. Jacobson DM, Moster ML, Eggenberger ER et al. Isolated trochlear nerve palsy in patients with multiple sclerosis. Neurology 1999;53(4):877-9. DOI: 10.1212/wnl.53.4.877
17. Durgam A, Hussain H, Nakatsuka AS, Raghuram K. Isolated trochlear nerve (cranial nerve IV) palsy in a patient with carotid-cavernous fistula. BJR Case Rep 2018;5(1):20180028. DOI: 10.1259/bjrcr.20180028
18. Tay KWE, Chua SGK. Isolated Trochlear Nerve Palsy in Post Traumatic Brain Injury: Incidental Detection Using Vestibular Screening Tests. Ann Clin Case Rep 2018;3:1531.
19. Lei J, Li Y, Wan X et al. Hemorrhagic schwannoma of the trochlear nerve:Case report and a review of the literature. Front Oncol 2023;12: 1097155. DOI: 10.3389/fonc.2022.1097155
20. Bhansali AP, Stamates MM, Lee JM, Wong RH. Solitary Infiltrating Meningioma of the Trochlear Nerve: Case Report. J Neurol Surg Rep 2018;79(2):e63-e64. DOI: 10.1055/s-0038-1661005
21. Lee SU, Choi JY, Kim HJ et al. Central Trochlear Palsy as an Isolated Finding with Metastatic Tumor. J Clin Neurol 2018;14(2):254-6. DOI: 10.3988/jcn.2018.14.2.254
22. Abkur TM. Trochlear nerve palsy. Pract Neurol 2017;17(6):474-5. DOI: 10.1136/practneurol-2017-001726
23. Al Kahtani ES, Khandekar R, Al-Rubeaan K et al. Assessment of the prevalence and risk factors of ophthalmoplegia among diabetic patients in a large national diabetes registry cohort. BMC Ophthalmol 2016;16:118. DOI: 10.1186/s12886-016-0272-7
24. Hayashi T, Nomura K, Nishiyama Y, Kimura K. Unilateral Isolated Trochlear Nerve Palsy due to Ipsilateral Midbrain Infarction. J Nippon Med Sch 2021;88(6):561-3. DOI: 10.1272/jnms.JNMS.2021_88-515
25. Robles LA. Central Trochlear Nerve Palsy due to Stroke: Report and Clinical Correlation of Two Cases. Can J Neurol Sci 2016;43(3):417-9. DOI: 10.1017/cjn.2015.344
26. Han S, Kim BK, Yum KS. Unusual manifestation of heat stroke: Isolated trochlear nerve palsy. J Stroke Cerebrovasc Dis 2020;29(10):105105. DOI: 10.1016/j.jstrokecerebrovasdis.2020.105105
27. Tamhankar MA, Ying GS, Volpe NJ. Success of prisms in the management of diplopia due to fourth nerve palsy. J Neuroophthalmol 2011;31(3):206-9. DOI: 10.1097/WNO.0b013e318211daa9
28. Chou KL, Galetta SL, Liu GT et al. Acute ocular motor mononeuropathies: prospective study of the roles of neuroimaging and clinical assessment.
J Neurol Sci 2004;219(1-2):35-9. DOI: 10.1016/j.jns.2003.12.003
29. Murchison AP, Gilbert ME, Savino PJ. Neuroimaging and acute ocular motor mononeuropathies: a prospective study. Arch Ophthalmol 2011;129(3):301-5. DOI: 10.1001/archophthalmol.2011.25
30. Prasad S, Volpe NJ. Paralytic Strabismus: Third, Fourth, and Sixth Nerve Palsy. Neurol Clin 2010;28(3):803-33. DOI: 10.1016/j.ncl.2010.04.001
31. Kruit MC, van Buchem MA, Launer LJ et al. Migraine is associated with an increased risk of deep white matter lesions, subclinical posterior circulation infarcts and brain iron accumulation: the population-based MRI CAMERA study. Cephalalgia 2010;30(2):129. DOI: 10.1111/j.1468-2982.2009.01904.x
32. Yang CP, Chen YT, Fuh JL, Wang SJ. Migraine and Risk of Ocular Motor Cranial Nerve Palsies: A Nationwide Cohort Study. Ophthalmology 2016;123(1):191-7. DOI: 10.1016/j.ophtha.2015.09.003
33. Akagi T, Miyamoto K, Kashii S, Yoshimura N. Cause and prognosis of neurologically isolated third, fourth, or sixth cranial nerve dysfunction in cases of oculomotor palsy. Jpn J Ophthalmol 2008;52(1):32-5. DOI: 10.1007/ s10384-007-0489-3

For citation:Belova A.N., Sheiko G.E., Grigoryeva V.N., Kliuev E.A., Rasteryaeva M.V. Isolated trochlear nerve palsy: case report and modern considerations. Clinical review for general practice. 2024; 5 (8): 96–101 (In Russ.). DOI: 10.47407/kr2024.5.8.00466


All accepted articles publish licensed under a Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

  • About
  • Editorial board
  • Ethics
  • For authors
  • Author fees
  • Peer review
  • Contacts

oa
crossref
анри


  Indexing

doaj
elibrary

Address of the Editorial Office:

127055, Moscow, s/m 37

Correspondence address:

115054, Moscow, Zhukov passage, 19, fl. 2, room XI


Managing Editor:

+7 (495) 926-29-83

id@con-med.ru