Clinical review for general practice

ISSN (Print) 2713-2552
ISSN (Online) 2782-5671
  • Home
  • about
  • archives
  • contacts
left
FULLSCREEN > Archive > 2024 > Vol 5, №9 (2024) > Course of pregnancy and labor in women with type 2 diabetes mellitus and obesity

Course of pregnancy and labor in women with type 2 diabetes mellitus and obesity

Galina A. Batrak , Nataliya V. Batrak

For citation:


  • Abstract
  • About the Author
  • References

Abstract

Maternal diabetes is associated with pregnancy complications and increased rates of adverse maternal and neonatal outcomes. Short-term complications include macrosomia, large for gestational age, respiratory distress syndrome, neonatal hypoglycemia, neonatal intensive care unit admission, fetal growth restriction, congenital anomalies, preterm birth, preeclampsia, operative delivery, while in the long term both mothers and their infants have an increased risk of metabolic diseases. The results of the conducted scientific study confirm that type 2 diabetes and obesity are closely associated with pregnancy complications: early and late threatened miscarriage, cervical insufficiency, hyperemesis gravidarum, anemia, chronic and gestational hypertension, moderate and severe preeclampsia, premature detachment of a normally located placenta, placental insufficiency, fetal growth retardation syndrome, pathological and insufficient weight gain, diabetic fetopathy of the fetus in the form of macrosomia, double contour of the fetal head/trunk, hepatomegaly, splenomegaly, pyelectasis of the fetal kidneys, congenital malformations of the fetus, intrauterine fetal death, prenatal rupture of membranes, clinically narrow pelvis, operative delivery, premature birth and, as a result, a low assessment of the newborn on the Apgar scale at 1 and 5 minutes. 
Keywords: type 2 diabetes mellitus, obesity, complications of pregnancy, childbirth and fetal development.

About the Author

Galina A. Batrak 1 , Nataliya V. Batrak 1

1 Ivanovo State Medical University, Ivanovo, Russia

References

1. Батрак Г.А., Мясоедова С.Е., Бродовская А.Н. Роль самоконтроля
гликемии в снижении риска развития диабетических микро- и
макроангиопатий. Consilium Medicum. 2019;21(12):55-8.
Batrak G.A., Myasoedova S.E., Brodovskaya A.N. The role of self-control of glycemia in reducing the risk of developing diabetic micro- and
macroangiopathies. Consilium Medicum. 2019;21(12):55-8 (in Russian).
2. Al-Rifai RH, Majeed M, Qambar MA et al. Type 2 diabetes and pre-diabetes mellitus: a systematic review and meta-analysis of prevalence
studies in women of childbearing age in the Middle East and North
Africa, 2000–2018. Springer. November 2019. Systematic Reviews.
2019; 8(1): 268. DOI: 10.1186/s13643-019-1187-1
3. Langer O. Prevention of Obesity and Diabetes in Pregnancy: Is It an Impossible Dream? Am. J Obstet Gynecol 2018;218:581-9. DOI:
10.1016/j.ajog.2018.03.014
4. Malaza N, Masete M, Adam S et al. A Systematic Review to Compare
Adverse Pregnancy Outcomes in Women with Pregestational Diabetes
and Gestational Diabetes. Int J Environ Res Public Health
2022;19(17):10846. DOI: 10.3390/ijerph191710846
5. Johns EC, Denison FC, Norman JE et al. Gestational Diabetes Mellitus:
Mechanisms, Treatment, and Complications. Trends Endocrinol Metab
2018;29:743-54. DOI: 10.1016/j.tem.2018.09.004
6. Sugrue R, Zera C. Pregestational Diabetes in Pregnancy. Obstet Gynecol Clin 2018;45:315-31. DOI: 10.1016/j.ogc.2018.01.002
7. Burlina S, Dalfrà M, Lapolla A. Short-and Long-Term Consequences for
Offspring Exposed to Maternal Diabetes: A Review. J Matern-Fetal
Neonatal Med 2019;32:687-694. DOI: 10.1080/14767058.2017.1387893
8. Zhu Y, LiuX, XuY et al. Hyperglycemia disturbs trophoblast functions
and subsequently leads to failure of uterine spiral artery remodeling.
Front Endocrinol (Lausanne) 2023;14:1060253. DOI: 10.3389/
fendo.2023.1060253
10. Li M, Huang Y, Xi H et al. Circ_FOXP1 promotes the growth and survival of high glucose-treated human trophoblast cells through the regulation of miR-508-3p/SMAD family member 2 pathway. Endocr J
2022;69(9):1067-78. DOI: 10.1507/endocrj.EJ21-0528
11. Zhou X, Xiang C, Zheng X. MiR-132 serves as a diagnostic biomarker in
gestational diabetes mellitus and its regulatory effect on trophoblast
cell viability. Diagn Pathol. 2019:14(1):119. DOI: 10.1186/s13000-019-
0899-9
12. Peng HY, Li MQ, Li HP. High glucose suppresses the viability and proliferation of HTR−8/SVneo cells through regulation of the miR137/PRKAA1/IL-6 axis. Int J Mol Med 2018;42:799-810. DOI:
10.3892/ijmm.2018.3686
13. Zhang C, Wang L, Chen J et al. Differential expression of miR-136 in
gestational diabetes mellitus mediates the high-Glucose-Induced trophoblast cell injury through targeting E2F1. Int J Genomics
2020;2020:3645371. DOI: 10.1155/2020/3645371
14. Wen J, Bai X. MiR-520h inhibits cell survival by targeting mTOR in
gestational diabetes mellitus. Acta Biochim Pol 2021;68:65-70. DOI:
10.18388/abp.2020_538910
15. Lai R, Ji L, Zhang X et al. Stanniocalcin2 inhibits the epithelial-mesenchymal transition and invasion of trophoblasts via activation of autophagy under high-glucose conditions. Mol Cell Endocrinol
2022;547:111598. DOI: 10.1016/j.mce.2022.111598
16. Peng HY, Li MQ, Li HP. MiR-137 restricts the viability and migration of
HTR-8/SVneo cells by downregulating FNDC5 in gestational diabetes
mellitus. Curr Mol Med 2019;19(7):494-505. DOI: 10.2174/1566524
019666190520100422
17. Sun DG, Tian S, Zhang L et al. The miRNA-29b is downregulated in placenta during gestational diabetes mellitus and may alter placenta development by regulating trophoblast migration and invasion through a
HIF3A-dependent mechanism. Front Endocrinol (Lausanne) 2020;11:
69. DOI: 10.3389/fendo.2020.00169
18. Nteeba J, Varberg KM, Scott RL et al. Poorly controlled diabetes mellitus alters placental structure, efficiency, and plasticity. BMJ Open Diabetes Res Care 2020;8(1):e001243. DOI: 10.1136/bmjdrc-2020-
001243
19. Tao J, Xia LZ, Chen JJ et al. High glucose condition inhibits trophoblast
proliferation, migration and invasion by downregulating placental
growth factor expression. J Obstet Gynaecol Res 2020;46:1690-701.
DOI: 10.1111/jog.1434112
20. Al-Ofi E, Alrafiah A, Maidi S et al. Altered expression of angiogenic biomarkers in pregnancy associated with gestational diabetes. Int J Gen
Med 2021;14:3367-75. DOI: 10.2147/IJGM.S31667015

For citation:Batrak G.A., Batrak N.V. Course of pregnancy and labor in women with type 2 diabetes mellitus and obesity. Clinical review for general practice. 2024; 5 (9): 57–61 (In Russ.). DOI: 10.47407/kr2024.5.9.00479


All accepted articles publish licensed under a Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

  • About
  • Editorial board
  • Ethics
  • For authors
  • Author fees
  • Peer review
  • Contacts

oa
crossref
анри


  Indexing

doaj
elibrary

Address of the Editorial Office:

127055, Moscow, s/m 37

Correspondence address:

115054, Moscow, Zhukov passage, 19, fl. 2, room XI


Managing Editor:

+7 (495) 926-29-83

id@con-med.ru