Abstract
Traditional methods of glycemic assessment, such as glycated hemoglobin (HbA1c) and the oral glucose tolerance test, may not reflect all aspects of carbohydrate metabolism, especially at the prediabetes stage.
Aim. To compare ambulatory glucose profiles obtained using the FreeStyle Libre 1 system in individuals with normal carbohydrate tolerance and dysglycemia.
Materials and methods. A single-center observational study including 32 patients (aged 31 to 72 years) with risk factors for type 2 diabetes mellitus. Anthropometric parameters, biochemical blood analysis, and continuous glucose monitoring (CGM) data over 14 days were assessed.
Results. Patients with prediabetes showed no statistically significant differences from healthy individuals in HbA1c levels; however, they exhibited higher levels of average glucose (AG) and the glucose management indicator (GMI). Time in tight target range (TITR) was significantly greater in the dysglycemia group. Correlations between glucose metrics varied depending on the presence of dysglycemia.
Conclusion. Continuous glucose monitoring allows for a more accurate assessment of glycemic control metrics and may be useful for early interventions in individuals at high risk of diabetes. Further research is needed to optimize the use of CGM and develop individualized intervention strategies.
Keywords: continuous glucose monitoring, glucose intolerance, prediabetes, glycemic variability, glycemic control, diabetes prevention.
Aim. To compare ambulatory glucose profiles obtained using the FreeStyle Libre 1 system in individuals with normal carbohydrate tolerance and dysglycemia.
Materials and methods. A single-center observational study including 32 patients (aged 31 to 72 years) with risk factors for type 2 diabetes mellitus. Anthropometric parameters, biochemical blood analysis, and continuous glucose monitoring (CGM) data over 14 days were assessed.
Results. Patients with prediabetes showed no statistically significant differences from healthy individuals in HbA1c levels; however, they exhibited higher levels of average glucose (AG) and the glucose management indicator (GMI). Time in tight target range (TITR) was significantly greater in the dysglycemia group. Correlations between glucose metrics varied depending on the presence of dysglycemia.
Conclusion. Continuous glucose monitoring allows for a more accurate assessment of glycemic control metrics and may be useful for early interventions in individuals at high risk of diabetes. Further research is needed to optimize the use of CGM and develop individualized intervention strategies.
Keywords: continuous glucose monitoring, glucose intolerance, prediabetes, glycemic variability, glycemic control, diabetes prevention.
For citation:Kovarenko M.A., Ruyatkina L.A., Ilushchenko A.A., Anmut V.A. Early dysglycemia in continuous glucose monitoring metrics. Clinical review for general practice. 2025; 6 (10): 24–31 (In Russ.). DOI: 10.47407/kr2025.6.10.00689
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