"Renaissance of reproductive losses", or New possibilities for overcoming implantation failures associated with chronic endometritis

Mekan R. Orazov , Viktor E. Radzinskii , Lyudmila M. Mikhaleva , Elena S. Silantieva , Evgenii D. Dolgov

For citation:

Abstract

Early reproductive losses represent one of the most relevant but unresolved issues of today’s reproductive medicine. To date, it has been proven that embryonic and endometrial factors play equal roles in realization of reproductive failures. Endometrial dysfunction, fibrosis, impaired endometrial receptivity/selectivity are the main causes of the endometrium-associated reproductive losses, which are most common in patients with the morphologically verified chronic endometritis (CE). To date, the world lacks the criteria for CE grading based on its severity. The paper reports new approaches to CE stratification based on severity, as well as options for pathogenetically justified therapy, based on domestic and international data.
Keywords: reproductive losses, implantation failures, endometrial factor, chronic endometritis, physical therapy, antifibrotic therapy, bovhyaluronidase azoximer.

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For citation:Orazov M.R., Radzinskii V.E., Mikhaleva L.M., Silantieva E.S., Dolgov E.D. "Renaissance of reproductive losses", or New possibilities for overcoming implantation failures associated with chronic endometritis. Clinical review for general practice. 2025; 6 (2): 66–72 (In Russ.). DOI: 10.47407/kr2025.6.2.00571

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Clinical review for general practice