Clinical review for general practice

ISSN (Print) 2713-2552
ISSN (Online) 2782-5671
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FULLSCREEN > Archive > 2025 > Vol 6, №3 (2025) > Primary prevention of early postoperative right ventricular failure: clinical experience with the use of levosimendan before implantation of a left ventricular assist device

Primary prevention of early postoperative right ventricular failure: clinical experience with the use of levosimendan before implantation of a left ventricular assist device

Kamil G. Ganaev , Oleg Yu. Narusov , Zhanna A. Shahramanova , Anatoliy G. Dragnev , Elina E. Vlasovа , Elena V. Dzybinskaya , Sergey N. Tereshchenko , Andrey A. Shiryaev , Renat S. Akchurin

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Abstract

Early right ventricular failure after left ventricular assist device (LVAD) implantation is one of the main causes of a worse postoperative prognosis. The problem of de novo right ventricular failure requires the search for methods of primary prevention and improvement of treatment strategies in its development. Preoperative therapy with levosimendan has a positive effect on right ventricular function and may be considered as a method of preoperative preparation for LVAD implantation.
Keywords: chronic heart failure, mechanical circulatory support, left ventricular assist device.

About the Author

Kamil G. Ganaev 1 , Oleg Yu. Narusov 1 , Zhanna A. Shahramanova 1 , Anatoliy G. Dragnev 1 , Elina E. Vlasovа 1 , Elena V. Dzybinskaya 1 , Sergey N. Tereshchenko 1 , Andrey A. Shiryaev 1 , Renat S. Akchurin 1

1 Chazov National Medical Research Center of Cardiology, Moscow, Russia

References

1. Varshney, Anubodh S et al. Trends and Outcomes of Left Ventricular Assist Device Therapy: JACC Focus Seminar. J Am College Cardiol 2022;79(11):1092-07. DOI: 10.1016/j.jacc.2022.01.017
2. Bravo, Claudio A et al. Right heart failure after left ventricular assist device: From mechanisms to treatments. Frontiers in Cardiovascular Medicine 2022;9:1023549. DOI: 10.3389/fcvm.2022.1023549
3. Шахраманова Ж.А., Аманатова В.А., Нарусов О.Ю. и др. Особенности оценки гемодинамики у пациентов с центрифугальной системой вспомогательного кровообращения. Кардиологический вестник. 2023;18(3):6-15. DOI: 10.17116/Cardiobulletin2023180316
Shakhramanova J.A., Amanatova V.A., Narusov O.Yu. et al. Features of hemodynamic assessment in patients with a centrifuge circulatory system. Cardiological Bulletin. 2023;18(3):6-15. DOI: 10.17116/Cardiobulletin2023180316 (in Russian).
4. Kirklin JK, Pagani FD, Kormos RL et al. Eighth annual INTERMACS report: special focus on framing the impact of adverse events. J Hear Lung Transplant 2017;36(10):1080-6. DOI: 10.1016/j.healun.2017. 07.005
5. Kivikko M, Antila S, Eha J et al. Pharmacodynamics and safety of a new calcium sensitizer, levosimendan, and its metabolites during an extended infusion in patients with severe heart failure. J Clin Pharmacol 2002;42(1):43-51.
6. Mehta RH, Leimberger JD, Van Diepen S et al. Levosimendan in patients with left ventricular dysfunction undergoing cardiac surgery. N Engl J Med 2017;376(21):2032-42.
7. Landoni G, Lomivorotov VV, Alvaro G et al. Levosimendan for hemodynamic support after cardiac surgery. N Engl J Med 2017;376(21): 2021-31.
8. Papp Z, Csapo K, Pollesello P et al. Pharmacological mechanisms contributing to the clinical efficacy of levosimendan. Cardiovasc. Drug Rev 2005;23:71-98.
9. Haikala H, Kaivola J, Nissinen E et al. Cardiac troponin C as a target protein for a novel calcium sensitizing drug, levosimendan. J Mol Cell Cardiol 1995;27:1859-866.
10. Nieminen MS, Pollesello P, Vajda G, Papp Z. Effects of levosimendan on the energy balance: Preclinical and clinical evidence. J Cardiovasc Pharmacol 2009;53:302-10.
11. Kopustinskiene DM, Pollesello P, Saris NE. Levosimendan is a mitochondrial K (ATP) channel opener. Eur J Pharmacol 2011;428:311-4.
12. Bakar SN, Jia S, Smith SJ. Right ventricular failure management. Curr Opin Cardiol 2019;34(2):213-7. DOI:10.1097/HCO.0000000000000 595
13. Ганаев К.Г., Дзыбинская Е.В., Нарусов О.Ю. и др. Госпитальные результаты имплантации центрифугальной системы поддержки функции левого желудочка пациентам с терминальной хронической сердечной недостаточностью (опыт НМИЦК им. ак. Е.И. Чазова). Российский кардиологический журнал. 2024;29 (6):5846. DOI: 10.15829/1560-4071-2024-5846
Ganeev K.G., Dzybinskaya E.V., Narusov O.Yu. et al. Hospital results of implantation of a centrifuge system to support left ventricular function in patients with terminal chronic heart failure (experience of the Chazov National Research Medical Center). Russian Journal of Cardiology. 2024;29(6):5846. DOI: 10.15829/1560-4071-2024-5846 (in Russian).
14. Frazier OH, Delgado RM. Mechanical circulatory support for advanced heart failure: where does it stand in 2003? Circulation 2003;108:3064-8.

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For citation:Ganaev K.G., Narusov O.Yu., Shahramanova Zh.A., Dragnev A.G., Vlasovа E.E., Dzybinskaya E.V., Tereshchenko S.N., Shiryaev A.A., Akchurin R.S. Primary prevention of early postoperative right ventricular failure: clinical experience with the use of levosimendan before implantation of a left ventricular assist device. Clinical review for general practice. 2025; 6 (3): 24–28 (In Russ.). DOI: 10.47407/kr2024.6.3.00579


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