Ekaterina V. Zadionchenko , Irina V. Zvezdina , Maria E. Arkatova
Abstract
The steady increase in the incidence of atopic dermatitis has recently been an alarming event, and the fact that this dermatosis in the vast majority of cases affects the children's population largely increases its social significance. The identification and study of various aspects of etiopathogenesis of atopic dermatitis from all kinds of angles allows us to adjust the therapeutic approach to such patients, to relieve suffering and improve the quality of life of patients. The impact on the atopics altered by the microbia is an integral part of the therapeutic strategy.
Keywords: atopic dermatitis, microbiota of the skin, pathogenesis.
Keywords: atopic dermatitis, microbiota of the skin, pathogenesis.
About the Author
Ekaterina V. Zadionchenko 1 , Irina V. Zvezdina 1 , Maria E. Arkatova 11 Russian University of Medicine, Moscow, Russia
References
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6. Siegels D, Heratizadeh A, Abraham S, et al. Systemic treatments in the management of atopic dermatitis: A systematic review and meta-analysis. Allergy. 2021;76(4):1053-76.
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Nikolaeva M.Yu., Monakhov K.N., Sokolovskiy E.V. Disorders of the skin microbiome in atopic dermatitis and psoriasis. Vestnik dermatologii i venerologii. 2021;97(6):33-43. DOI: 10.25208/vdv1282 (in Russian).
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11. Dréno B, Dagnelie MA, Khammari A, Corvec S. The skin microbiome: a new actor in inflammatory acne. Am J Clin Dermatol. 2020;21(Suppl. 1):18-24.
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Murashkin N.N., Pavlova E.S., Epishev R.V., et al. Skin Microbiome Composition and Key Factors of its Barrier Function. Current Pediatrics. 2023;22(5):387-92. DOI: 10.15690/vsp.v22i5.2624 (in Russian).
13. Carmona-Cruz S, Orozco-Covarrubias L, Sáez-de-Ocariz M. The human skin microbiome in selected cutaneous diseases. Front Cell Infect Microbiol. 2022;12:834135.
14. Iwase T, Uehara Y, Shinji H, et al. Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization. Nature. 2010 May 20;465(7296):346-9. DOI: 10.1038/nature09074
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16. Vijaya Chandra SH, Srinivas R, Dawson TL Jr, Common JE. Cutaneous Malassezia: commensal, pathogen, or protector? Front Cell Infect Microbiol. 2021;10:614446.
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18. Pinto D, Ciardiello T, Franzoni M, et al. Effect of commonly used cosmetic preservatives on skin resident microflora dynamics. Sci Rep. 2021;11(1):8695.
19. Nedoszytko B, Reszka E, Gutowska-Owsiak D, et al. Genetic and epigenetic aspects of atopic dermatitis. Int J Mol Sci. 2020;21(18):6484.
20. Hrestak D, Matijašić M, Čipčić Paljetak H, et al. Skin microbiota in atopic dermatitis. Int J Mol Sci. 2022;23(7):3503.
21. Pothmann A, Illing T, Wiegand C, et al. The microbiome and atopic dermatitis: a review. Am J Clin Dermatol. 2019;20:749-61.
22. Fölster-Holst R. The role of the skin microbiome in atopic dermatitis – correlations and consequences. J Dtsch Dermatol Ges. 2022 May;20(5):571-7. DOI: 10.1111/ddg.14709
23. Qiu Z, Zhu Z, Liu X, et al. A dysregulated sebum-microbial metabolite-IL-33 axis initiates skin inflammation in atopic dermatitis. J Exp Med. 2022 Oct 3;219(10):e20212397. DOI: 10.1084/jem.20212397
24. Zhang XE, Zheng P, Ye SZ, et al. Microbiome: role in inflammatory skin diseases. J Inflamm Res. 2024 Feb 15:17:1057-82. DOI: 10.2147/JIR. S441100
25. Kim K, Jang H, Kim E, et al. Recent advances in understanding the role of the skin microbiome in the treatment of atopic dermatitis. Exp Dermatol. 2023;32(12):2048-61.
26. Chen Y, Knight R, Gallo RL. Evolving approaches to profiling the microbiome in skin diseas. Front Immunol. 2023;14:1151527.
27. Kurniadi I, Hendra Wijaya W, Timotius KH. Malassezia virulence factors and their role in dermatological disorders. Acta Dermatovenerol Alp Pannonica Adriat. 2022 Jun;31(2):65-70.
28. Jung WH. Alteration in skin mycobiome due to atopic dermatitis and seborrheic dermatitis. Biophys Rev (Melville). 2023;4(1):011309.
29. Storz L, Schmid B, Bosshard PP, et al. Decreased skin colonization with Malassezia spp. and increased skin colonization with Candida spp. in patients with severe atopic dermatitis. Front Med (Lausanne). 2024;11:1353784.
30. Kobiela A, Frackowiak JE, Biernacka A, et al. Exposure of keratinocytes to Candida albicans in the context of atopic milieu induces changes in the surface glycosylation pattern of small extracellular vesicles to enhance their propensity to interact with inhibitory Siglec receptors. Front Immunol. 2022;13:884530.
31. Belfrage E, Jinnestål CL, Jönsen A, et al. Role of mannose-binding lectin and association with microbial sensitization in a cohort of patients with atopic dermatitis. Acta Derm Venereol. 2023 Mar 30;103:adv2405. DOI: 10.2340/actadv.v103.2405
32. Salvati L, Cosmi L, Annunziato F. From emollients to biologicals: targeting atopic dermatitis. Int J Mol Sci. 2021;22(19):10381.
33. Elsgaard S, Danielsen AK, Thyssen JP, et al. Drug survival of systemic immunosuppressive treatments for atopic dermatitis in a long-term pediatric cohort. Int J Women’s Dermatol. 2021;7(5):708-15.
34. Ferrucci SM, Tavecchio S, Marzano AV, Buffon S. Emerging systemic treatments for atopic dermatitis. Dermatol Ther (Heidelberg). 2023;13(5):1071-81.
35. Edslev SM, Agner T, Andersen PS. Skin microbiome in atopic dermatitis. Acta Derm Venereol. 2020;100(12):adv00164.
36. Khadka VD, Key FM, Romo-González C, et al. The skin microbiome of patients with atopic dermatitis normalizes gradually during treatment. Front Cell Infect Microbiol. 2021;11:720674.
37. Harder I, Stölzl D, Sander N, et al. Effects of early emollient use in children at high risk of atopic dermatitis: a German pilot study. Acta Derm Venereol. 2023;103:adv5671.
38. Krzysiek J, Żurawska-Olszewska J, Szczerba I, et al. Shift in skin microbiota of children with atopic dermatitis after topical gentian violet application. Postepy Dermatol Alergol. 2023;40(2):308-14.
39. Stolarczyk A, Perez-Nazario N, Knowlden SA, et al. Bleach baths enhance skin barrier, reduce itch but do not normalize skin dysbiosis in atopic dermatitis. Arch Dermatol Res. 2023;315(10):2883-92.
40. Dewi DAR, Perdiyana A, Wiliantari NM, et al. Managing the skin microbiome as a new bacteriotherapy for inflammatory atopic dermatitis. Cureus. 2023;15(11):e48803.
41. Lossius AH, Sundnes O, Ingham AC, et al. Shifts in the skin microbiota after UVB treatment in adult atopic dermatitis. Dermatology. 2022;238(1):109-20.
42. Tsuji G, Yamamura K, Kawamura K, et al. Novel therapeutic targets for the treatment of atopic dermatitis. Biomedicines. 2023;11(5): 1303.
43. Мурашкин Н.Н., Намазова-Баранова Л.С., Опрятин Л.А. и др. Биологическая терапия среднетяжелых и тяжелых форм атопического дерматита в детском возрасте. Вопросы современной педиатрии. 2020;19(6):432-43. DOI: 10.15690/vsp.v19i6.2145
Murashkin N.N., Namazova-Baranova L.S., Opryatin L.A., et al. Biologic Therapy of Moderate and Severe Forms of Atopic Dermatitis in Children. Current Pediatrics. 2020;19(6):432-43. DOI: 10.15690/ vsp.v19i6.2145 (in Russian).
44. Olesen CM, Ingham AC, Thomsen SF, et al. Changes in skin and nasal microbiome and staphylococcal species following treatment of atopic dermatitis with dupilumab. Microorganisms. 2021;9(7):1487.
45. Simpson EL, Schlievert PM, Yoshida T, et al. Rapid reduction in Staphylococcus aureus in atopic dermatitis subjects following dupilumab treatment. J Allergy Clin Immunol. 2023 Nov;152(5): 1179-95. DOI: 10.1016/j.jaci.2023.05.026
Портал CON-MED.RU:
https://con-med.ru/magazines/klinicheskiy_razbor_v_obshchey_meditsine/klinicheskiy_razbor_v_obshchey_meditsine-04-2025/osobennosti_mikrobioma_kozhi_u_patsientov_s_atopicheskim_dermatitom/
2. Schuler CF 4th, Billi AC, Maverakis E, et al. Novel insights into atopic dermatitis. J Allergy Clin Immunol. 2023;151(5):1145-54. DOI: 10.1016/j.jaci.2022.10.023
3. Tian J, Zhang D, Yang Y, et al. Global epidemiology of atopic dermatitis: a comprehensive systematic analysis and modelling study. Brit J Dermatol. 2024;190(1):55-61.
4. Дроздов В.Н., Арефьев К.И., Сереброва С.Ю. и др. Эффективность и безопасность антигистаминных препаратов при атопическом дерматите у детей. Медицинский совет. 2021;(1):193-201. DOI: 10.21518/2079-701X-2021-1-193-201
Drozdov V.N., Arefev K.I., Serebrova S.Yu., et al. Efficacy and safety of antihistamines in children with atopic dermatitis. Meditsinskiy sovet = Medical Council. 2021;(1):193-201. DOI: 10.21518/2079-701X-2021-1-193-201 (in Russian).
5. Frazier W, Bhardwaj N. Atopic dermatitis: diagnosis and treatment. Am Fam Phys. 2020;101(10):590-8.
6. Siegels D, Heratizadeh A, Abraham S, et al. Systemic treatments in the management of atopic dermatitis: A systematic review and meta-analysis. Allergy. 2021;76(4):1053-76.
7. Ali F, Vyas J, Finlay AY. Counting the burden: atopic dermatitis and health-related quality of life. Acta Derm Venereol. 2020;100(12): adv00161. DOI: 10.2340/00015555-3511
8. Николаева М.Ю., Монахов К.Н., Соколовский Е.В. Нарушения микробиома кожи при атопическом дерматите и псориазе. Вестник дерматологии и венерологии. 2021;97(6):33-43. DOI: 10.25208/vdv1282
Nikolaeva M.Yu., Monakhov K.N., Sokolovskiy E.V. Disorders of the skin microbiome in atopic dermatitis and psoriasis. Vestnik dermatologii i venerologii. 2021;97(6):33-43. DOI: 10.25208/vdv1282 (in Russian).
9. Lee HJ, Kim M. Skin barrier function and the microbiome. Int J Mol Sci. 2022;23(21):13071.
10. Smythe P, Wilkinson HN. The skin microbiome: current landscape and future opportunities. Int J Mol Sci. 2023;24(4):3950.
11. Dréno B, Dagnelie MA, Khammari A, Corvec S. The skin microbiome: a new actor in inflammatory acne. Am J Clin Dermatol. 2020;21(Suppl. 1):18-24.
12. Мурашкин Н.Н., Павлова Е.С., Епишев Р.В. и др. Состав микробиома кожи и ключевые аспекты его барьерной функции. Вопросы современной педиатрии. 2023;22(5):387-92. DOI: 10.15690/vsp. v22i5.2624
Murashkin N.N., Pavlova E.S., Epishev R.V., et al. Skin Microbiome Composition and Key Factors of its Barrier Function. Current Pediatrics. 2023;22(5):387-92. DOI: 10.15690/vsp.v22i5.2624 (in Russian).
13. Carmona-Cruz S, Orozco-Covarrubias L, Sáez-de-Ocariz M. The human skin microbiome in selected cutaneous diseases. Front Cell Infect Microbiol. 2022;12:834135.
14. Iwase T, Uehara Y, Shinji H, et al. Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization. Nature. 2010 May 20;465(7296):346-9. DOI: 10.1038/nature09074
15. Wrześniewska M, Wołoszczak J, Świrkosz G, et al. The role of the microbiota in the pathogenesis and treatment of atopic dermatitis: a literature review. Int J Mol Sci. 2024;25(12):6539.
16. Vijaya Chandra SH, Srinivas R, Dawson TL Jr, Common JE. Cutaneous Malassezia: commensal, pathogen, or protector? Front Cell Infect Microbiol. 2021;10:614446.
17. Yang Y, Qu L, Mijakovic I, Wei Y. Advances in the human skin microbiota and its roles in cutaneous diseases. Microb Cell Factor. 2022;21(1):176.
18. Pinto D, Ciardiello T, Franzoni M, et al. Effect of commonly used cosmetic preservatives on skin resident microflora dynamics. Sci Rep. 2021;11(1):8695.
19. Nedoszytko B, Reszka E, Gutowska-Owsiak D, et al. Genetic and epigenetic aspects of atopic dermatitis. Int J Mol Sci. 2020;21(18):6484.
20. Hrestak D, Matijašić M, Čipčić Paljetak H, et al. Skin microbiota in atopic dermatitis. Int J Mol Sci. 2022;23(7):3503.
21. Pothmann A, Illing T, Wiegand C, et al. The microbiome and atopic dermatitis: a review. Am J Clin Dermatol. 2019;20:749-61.
22. Fölster-Holst R. The role of the skin microbiome in atopic dermatitis – correlations and consequences. J Dtsch Dermatol Ges. 2022 May;20(5):571-7. DOI: 10.1111/ddg.14709
23. Qiu Z, Zhu Z, Liu X, et al. A dysregulated sebum-microbial metabolite-IL-33 axis initiates skin inflammation in atopic dermatitis. J Exp Med. 2022 Oct 3;219(10):e20212397. DOI: 10.1084/jem.20212397
24. Zhang XE, Zheng P, Ye SZ, et al. Microbiome: role in inflammatory skin diseases. J Inflamm Res. 2024 Feb 15:17:1057-82. DOI: 10.2147/JIR. S441100
25. Kim K, Jang H, Kim E, et al. Recent advances in understanding the role of the skin microbiome in the treatment of atopic dermatitis. Exp Dermatol. 2023;32(12):2048-61.
26. Chen Y, Knight R, Gallo RL. Evolving approaches to profiling the microbiome in skin diseas. Front Immunol. 2023;14:1151527.
27. Kurniadi I, Hendra Wijaya W, Timotius KH. Malassezia virulence factors and their role in dermatological disorders. Acta Dermatovenerol Alp Pannonica Adriat. 2022 Jun;31(2):65-70.
28. Jung WH. Alteration in skin mycobiome due to atopic dermatitis and seborrheic dermatitis. Biophys Rev (Melville). 2023;4(1):011309.
29. Storz L, Schmid B, Bosshard PP, et al. Decreased skin colonization with Malassezia spp. and increased skin colonization with Candida spp. in patients with severe atopic dermatitis. Front Med (Lausanne). 2024;11:1353784.
30. Kobiela A, Frackowiak JE, Biernacka A, et al. Exposure of keratinocytes to Candida albicans in the context of atopic milieu induces changes in the surface glycosylation pattern of small extracellular vesicles to enhance their propensity to interact with inhibitory Siglec receptors. Front Immunol. 2022;13:884530.
31. Belfrage E, Jinnestål CL, Jönsen A, et al. Role of mannose-binding lectin and association with microbial sensitization in a cohort of patients with atopic dermatitis. Acta Derm Venereol. 2023 Mar 30;103:adv2405. DOI: 10.2340/actadv.v103.2405
32. Salvati L, Cosmi L, Annunziato F. From emollients to biologicals: targeting atopic dermatitis. Int J Mol Sci. 2021;22(19):10381.
33. Elsgaard S, Danielsen AK, Thyssen JP, et al. Drug survival of systemic immunosuppressive treatments for atopic dermatitis in a long-term pediatric cohort. Int J Women’s Dermatol. 2021;7(5):708-15.
34. Ferrucci SM, Tavecchio S, Marzano AV, Buffon S. Emerging systemic treatments for atopic dermatitis. Dermatol Ther (Heidelberg). 2023;13(5):1071-81.
35. Edslev SM, Agner T, Andersen PS. Skin microbiome in atopic dermatitis. Acta Derm Venereol. 2020;100(12):adv00164.
36. Khadka VD, Key FM, Romo-González C, et al. The skin microbiome of patients with atopic dermatitis normalizes gradually during treatment. Front Cell Infect Microbiol. 2021;11:720674.
37. Harder I, Stölzl D, Sander N, et al. Effects of early emollient use in children at high risk of atopic dermatitis: a German pilot study. Acta Derm Venereol. 2023;103:adv5671.
38. Krzysiek J, Żurawska-Olszewska J, Szczerba I, et al. Shift in skin microbiota of children with atopic dermatitis after topical gentian violet application. Postepy Dermatol Alergol. 2023;40(2):308-14.
39. Stolarczyk A, Perez-Nazario N, Knowlden SA, et al. Bleach baths enhance skin barrier, reduce itch but do not normalize skin dysbiosis in atopic dermatitis. Arch Dermatol Res. 2023;315(10):2883-92.
40. Dewi DAR, Perdiyana A, Wiliantari NM, et al. Managing the skin microbiome as a new bacteriotherapy for inflammatory atopic dermatitis. Cureus. 2023;15(11):e48803.
41. Lossius AH, Sundnes O, Ingham AC, et al. Shifts in the skin microbiota after UVB treatment in adult atopic dermatitis. Dermatology. 2022;238(1):109-20.
42. Tsuji G, Yamamura K, Kawamura K, et al. Novel therapeutic targets for the treatment of atopic dermatitis. Biomedicines. 2023;11(5): 1303.
43. Мурашкин Н.Н., Намазова-Баранова Л.С., Опрятин Л.А. и др. Биологическая терапия среднетяжелых и тяжелых форм атопического дерматита в детском возрасте. Вопросы современной педиатрии. 2020;19(6):432-43. DOI: 10.15690/vsp.v19i6.2145
Murashkin N.N., Namazova-Baranova L.S., Opryatin L.A., et al. Biologic Therapy of Moderate and Severe Forms of Atopic Dermatitis in Children. Current Pediatrics. 2020;19(6):432-43. DOI: 10.15690/ vsp.v19i6.2145 (in Russian).
44. Olesen CM, Ingham AC, Thomsen SF, et al. Changes in skin and nasal microbiome and staphylococcal species following treatment of atopic dermatitis with dupilumab. Microorganisms. 2021;9(7):1487.
45. Simpson EL, Schlievert PM, Yoshida T, et al. Rapid reduction in Staphylococcus aureus in atopic dermatitis subjects following dupilumab treatment. J Allergy Clin Immunol. 2023 Nov;152(5): 1179-95. DOI: 10.1016/j.jaci.2023.05.026
Портал CON-MED.RU:
https://con-med.ru/magazines/klinicheskiy_razbor_v_obshchey_meditsine/klinicheskiy_razbor_v_obshchey_meditsine-04-2025/osobennosti_mikrobioma_kozhi_u_patsientov_s_atopicheskim_dermatitom/
For citation:Zadionchenko E.V., Zvezdina I.V., Arkatova M.E. Features of skin microbiome in patients with atopic dermatitis. Clinical review for general practice. 2025; 6 (4): 85–91 (In Russ.). DOI: 10.47407/kr2025.6.4.00599
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