Bullous emphysema: causes, diagnosis, complications. Clinical and pathological study of the patient with bullous emphysema and fatal spontaneous pneumothorax

Sergey I. Viktorov , Daria S. Ivanova , Dinara B. Uralbaeva , Inna A. Viktorova

For citation:

Abstract

The clinical and pathological study of the patient having bullous emphysema complicated with spontaneous pneumothorax, the causes of which were not diagnosed antemortem, is reported. Phenotypic signs of connective tissue dysplasia, Williams–Campbell syndrome, and granuloma of the lung caused by fungal infection were diagnosed postmortem. The analysis of literature in terms of this clinical case emphasizes the need for detection of phenotypic and clinical signs of connective tissue dysplasia in patients with bullous emphysema, antemortem verification of hereditary connective tissue disorders with the timely referral of patients to genetic testing, development of individual rehabilitation and treatment program, which will make it possible to prevent premature deaths among this category of patients.

Keywords: bullous emphysema, spontaneous pneumothorax, connective tissue dysplasia, Williams–Campbell syndrome.

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For citation: Viktorov S.I., Ivanova D.S., Uralbaeva D.B., Viktorova I.A. Bullous emphysema: causes, diagnosis, complications. Clinical and pathological study of the patient with bullous emphysema and fatal spontaneous pneumothorax. Clinical review for general practice. 2025; 6 (6): 67–74 (In Russ.). DOI: 10.47407/kr2025.6.6.00632

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Clinical review for general practice