Abstract
Objective. To identify a possible correlation between the concentration of sCD14 and the severity of rheumatoid arthritis, to determine its role in the pathological process.
Material and methods. The literature review includes an analysis of scientific papers from the databases PubMed, MEDLINE, Embase, eLibrary, CyberLeninka and GoogleScholars.
Conclusion. CD14 performs several important and potentially different biological functions, including endotoxin binding, mediation of cellular apoptosis, as well as regulation of lymphocyte activation and function, and acts as an acute phase protein. sCD14 may serve as a potential "link" explaining the increased risk of cardiovascular disease observed in patients with rheumatoid arthritis.
Keywords: rheumatoid arthritis, CD14, monocytes.
For citation: Kaliberdenko V.B., Petrov A.V., Gorlov A.A., Zagidullina E.R., Pronkina T.S., Gorbenko E.S., Bаchalova D.I., Batkaeva A.I. The role of CD14 in the pathogenesis of rheumatoid arthritis. Clinical review for general practice. 2025; 6 (6): 86–89 (In Russ.). DOI: 10.47407/kr2025.6.6.00635
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