Abstract
Aim. To evaluate the efficacy and safety of using the complex herbal preparation Mabell Cycle in the treatment of stress-dependent menstrual disorders. Materials and methods. Prospective, open-label, non-interventional study was conducted with 80 patients aged 18–31 years (mean age 24.41±2.95 years) with stress-dependent menstrual disorders. The participants were ratio into two groups: the main group (n=40) received Mabelle Cycle (active ingredients: Trifolium pratense (red clover) extract, Vitex agnus-castus extract, Angelica sinensis root extract, Griffonia simplicifolia extract, D,L-phenylalanine, iron) at a dose of 2 tablets daily for 3 months, while the control group (n=40) received non-drug therapy (consultation with a psychologist, physiotherapy) following the same regimen. The duration of therapy was 3 months. Efficacy was assessed by menstrual cycle restoration, dynamics of premenstrual syndrome symptoms, and MEDI-Q questionnaire indicators. Safety assessent was based on the incidence of adverse reactions. Study design: prospective, open-label, non-interventional.
Results. The Mabell Cycle group showed progressive restoration of the menstrual cycle: 22.5%, 50.0%, and 62.5% of patients over three months of therapy compared to 7.5%, 17.5%, and 27.5% in the control group, respectively. Statistically significant differences were detected from the second month of therapy (p=0.008). The Mabell Cycle group showed significant reduction in mood lability (from 45.0% to 7.5%, p=0.015), mastalgia (from 40.0% to 10.0%, p=0.008), complete resolution of depressive symptoms (p<0.001), and improvement in five out of six evaluated psycho-emotional parameters versus three in the control group. The total MEDI-Q score in the Mabell Cycle group decreased from 58.00 to 33.00 (p=0.001), achieving significant intergroup differences by the end of the study (p=0.001).
Conclusion. The multitarget phytocomplex Mabell Сycle demonstrates high efficacy and safety in restoring the menstrual cycle in stress-dependent disorders. The use of a phytocomplex for 3 months provides significant improvement in cycle regularity, reduction in the severity of psycho-emotional and somatic symptoms, and enhancement of patients' quality of life. The results obtained allow recommending the phytocomplex Mabell Cycle for inclusion in clinical protocols for managing patients with stress-dependent menstrual disorders.
Keywords: stress-dependent amenorrhea, menstrual disorders, phytotherapy.
For citation: Radzinskiy V.E., Orazov M.R., Khamoshina M.B., Orekhov R.E., Mullina I.A., Lesnaya O.A. Clinical review for general practice. 2025; 6 (8): 86–94 (In Russ.). DOI: 10.47407/kr2025.6.8.00663
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