To the question of the influence of gut microbiota in the development of Alzheimer's disease

Ashime Sh. Asanova , Elena N. Primysheva , Marlen A. Ablaev , Lilia Z. Kokosadze , Daria A. Gorpinich , Anna V. Lesik , Fouad G. Saab , Zeinep S. Khalilova

For citation:

Abstract

Dementia is a major medical and social problem, the significance of which is growing every year due to the increase in the proportion of elderly people in the population. To date, data from both laboratory and clinical studies are accumulating, which prove the influence of intestinal microbiota on the development of neurodegenerative diseases. This article summarizes the literature data on the potential impact of intestinal microbiota dysfunction on the development of Alzheimer's disease, and describes biomarkers of intestinal microbiota and its metabolites, which can serve as a reliable tool for early and reliable diagnosis of Alzheimer's disease. We conducted a systematic search and analysis of scientific papers in the PubMed and Google Scholar databases using the terms "gut-brain axis", "intestinal microbiota", "Alzheimer's disease", "dementia".

Keywords: Alzheimer's disease, gut-brain axis, gut microbiota, gut microbiota biomarkers.

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For citation: Asanova A.Sh., Primysheva E.N., Ablaev M.A., Kokosadze L.Z., Gorpinich D.A., Lesik A.V., Saab F.G., Khalilova Z.S. To the question of the influence of gut microbiota in the development of Alzheimer's disease. Clinical review for general practice. 2025; 6 (8): 18–21 (In Russ.). DOI: 10.47407/kr2025.6.8.00653

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Clinical review for general practice