Abstract
Hyperprolactinemia, a condition characterized by elevated prolactin levels, is associated with various organic and functional factors, including pituitary adenomas, stress, hypothyroidism, and polycystic ovary syndrome (PCOS). This study investigates the impact of hyperprolactinemia on mineral metabolism and reproductive function in women, focusing on those with hypothyroidism and PCOS.
Aim. To study the effect of hyperprolactinemia on mineral metabolism in women with hyperprolactinemia syndrome and optimize the restoration of their reproductive function.
Materials and methods. A total of 134 women of reproductive age were included in the study, divided into two main groups: women with hypothyroidism and hyperprolactinemia (n=52) and women with PCOS and hyperprolactinemia (n=42). A control group of 40 healthy women was also included. The study was conducted in two stages: the first stage involved selecting women based on their underlying conditions and dividing them into subgroups based on treatment protocols (pathogenetic therapy with or without mineral complexes and vitamin D). The second stage focused on monitoring hormonal, biochemical, and obstetric outcomes in women who became pregnant after treatment.
Results. Key findings revealed that women with hyperprolactinemia, particularly those with PCOS, exhibited significant hormonal imbalances, including elevated LH levels, insulin resistance, and reduced bone mineral density. The addition of mineral complexes and vitamin D to standard treatment significantly improved pregnancy rates and reduced obstetric complications such as miscarriage, gestational hypertension, and preeclampsia. Women receiving combined treatment had higher pregnancy rates and fewer complications compared to those receiving only standard therapy. The study concludes that hyperprolactinemia significantly affects mineral metabolism and reproductive health, leading to complications such as osteopenia, hormonal dysregulation, and adverse pregnancy outcomes. The average calcium levels, which are key indicators of mineral metabolism, showed a significant difference between the groups. In women with hypothyroidism and hyperprolactinemia, the calcium level was 1.8±0.01, which was significantly lower than the normal range. In women with PCOS and hyperprolactinemia, this level was found at the lowest threshold of the normal range, which we attributed to the relative hyperestrogenism and androgenism in these women.
Conclusion. The inclusion of mineral supplements and vitamin D in the treatment regimen not only enhances reproductive function but also mitigates the risk of obstetric complications, highlighting the importance of a comprehensive approach to managing hyperprolactinemia in women with hypothyroidism and PCOS.
Keywords: hyperprolactinemia, mineral metabolism, osteopenia, pregnancy.
For citation:Matrizaeva G.D., Baltabaeva G.S., Muminova Z.A, Khaitov A.O., Ruzieva N.H., Ikramova Kh.S. Mineral metabolism and reproductive dysfunction in hyperprolactinemia. Clinical review for general practice. 2025; 6 (9): 26–36 (In Russ.). DOI: 10.47407/kr2025.6.9.00669
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