Clinical case of dermatomyosits in a patient with polycythemia vera and postpolychytemic myelofibrosis

Elena V. Zakharova , Tatyana A. Makarova , Inna M. Korablina , Sergey L. Vorobyev , Olga A. Vorobyeva

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Abstract

Polymyositis and dermatomyositis belong to the group of inflammatory myopathies, presenting with proximal muscular weakness and inflammatory changes of the muscles; dermatomyositis in addition characterized by different types of skin rush. Laboratory findings include elevated muscle enzymes levels, most of patients have myositis specific or myositis associated autoantibodies, or non-specific antinuclear antibodies. Association of dermatomyositis/polymyositis and cancer, mostly adenocarcinomas, is well established, while association with blood malignancies, such as non-Hodgkin lymphomas, myelodysplastic syndrome or primary myelofobrosis is much rarer. We found just a single case of dermatomyositis, associated with polycythemia vera and postpolychytemic myelofibrosis. Hereby we present a second to our knowledge case of a patient with polycythemia vera, postpolychytemic myelofibrosis and dermatomyositis, and discuss the difficulties of myopathy differential diagnostics.

Keywords: myopathy, biopsy, myeloproliferative disorders.

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For citation:Zakharova E.V., Makarova T.A., Korablina I.M., Vorobyev S.L., Vorobyeva O.A. Clinical case of dermatomyosits in a patient with polycythemia vera and postpolychytemic myelofibrosis. Clinical review for general practice. 2026; 7 (1): 21–26 (In Russ.). DOI: 10.47407/kr2026.7.1.00746

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Clinical review for general practice