Incretin therapy for obesity: efficacy, safety, and compliance

Mekan R. Orazov , Viktor E. Radzinskiy , Liudmila M. Mikhaleva , Vera E. Balan , Evgeniy D. Dolgov

For citation:

Abstract

Obesity remains one of the major comorbidities in the today’s world’s population that is of pandemic nature. Unfortunately, the rapid annual increase in the prevalence of obesity as a multisystemic disorder affecting almost all organs and systems is acknowledged. It has been proven that obesity increases the risk of polysomatic, carcinogenic disorders, including gynecological ones, and contributes to epigenetic remodeling of progeny genomes, inducing the endocrine/metabolic and cardiovascular disorders in the long term. The review provides details of the issue of efficacy, safety, and compliance in terms of incretin therapy for obesity.

Keywords: obesity, preclinical obesity, clinical obesity, diagnostic criteria, glucagon-like peptide-1 receptor agonist, dual glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor agonist, semaglutide, tirzepatide.

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For citation:Orazov M.R., Radzinskiy V.E., Mikhaleva L.M., Balan V.E., Dolgov E.D. Incretin therapy for obesity: efficacy, safety, and compliance. Clinical review for general practice. 2026; 7 (2): 115–122 (In Russ.). DOI: 10.47407/kr2026.7.2.00779

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Clinical review for general practice