Abstract
Aim. Oral mucosal lesions (OMLs) are a common pathology that significantly reduces quality of life. Platelet-rich fibrin (PRF) is a promising autologous biomaterial; however, its effectiveness in OM pathology requires systematic evaluation. The aim of this review is to summarize data on the efficacy of PRF for various OM lesions.
Materials and methods. A systematic search of PubMed, Scopus, Embase, and Web of Science databases was conducted until April 2024. Twelve studies were selected based on the inclusion criteria: 3 RCTs, 3 split-mouth studies, 2 prospective studies, 3 case reports, and 1 retrospective study.
Results. PRF was used in the form of membranes and injectables. Statistically significant acceleration of healing, reduction in lesion area, symptom regression, and a reduced recurrence rate were demonstrated compared to control groups. Histological analysis confirmed the regenerative and anti-inflammatory potential of PRF.
Conclusion. PRF-based therapy is a promising and safe treatment for oral mucosal lesions. Large-scale RCTs aimed at standardizing protocols and assessing long-term efficacy are needed for its practical implementation.
Keywords: platelet-rich fibrin, PRF, oral mucosal diseases, ulcerative lesions, oral mucositis, oral leukoplakia, lichen planus, wound healing, regenerative medicine.
For citation:Kaliberdenko V.B., Kadyrov R.D., Mamutov R.A., Ametov S.A., Muratova S.S., Azamatov A.A., Davletshin Z.A., Khusanova S.K. Regenerative properties of platelet-rich fibrin: application in oral lesions. Clinical review for general practice. 2026; 7 (2): 35–37 (In Russ.). DOI: 10.47407/kr2026.7.4.00816
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