Infective endocarditis of a native aortic valve of staphylococcal etiology in adolescents: a clinical case

Olga A. Korovina , Marina G. Kantemirova , Yuri N. Shamrin , Ketura Musonda , Alexey V. Bedin , Yulia Yu. Novikova , Dmitry Yu. Ovsyannikov , Mikhail A. Abramyan

For citation:

Abstract

Infective endocarditis (IE) in children is a rare but severe, potentially disabling and fatal disease. Diagnosis and treatment of patients with IE requires vigilance and the engagement of doctors of different specialties. The most difficult cases of IE to diagnose in children are in the absence of previously known changes in the heart valves, especially in cases of staphylococcal etiology and an acute course of the disease. This paper presents a clinical case of acute IE of a native aortic valve in a teenager, which clinically debuted as purulent meningitis associated with staphylococcal infection (Staphylococcus aureus). The aggressive infectious and destructive process in the heart resulted in the development of a fibrous ring abscess and subtotal destruction of the aortic valve. The combination of surgical treatment and targeted antibacterial therapy let to favourable outcome.

Keywords: infective endocarditis, diagnosis, treatment, adolescents, staphylococcal infection, aortic valve.

References

1. Демин А.А., Кобалава Ж.Д., Скопин И.И. и др. Инфекционный эндокардит и инфекция внутрисердечных устройств. Клинические рекомендации 2021. Российский кардиологический журнал. 2022;27(10):5233. DOI: 10.15829/1560-4071-2022-5233

Demin A.A., Kobalava Zh.D., Skopin I.I. et al. Infectious endocarditis and infection of intracardiac devices in adults. Clinical guidelines 2021. Russian Journal of Cardiology. 2022;27(10):5233. DOI: 10.15829/1560-4071-2022-5233 (in Russian).

2. Knirsch W, Nadal D. Infective endocarditis in congenital heart disease. Eur J Pediatr 2011;170(9):1111-27. DOI: 10.1007/s00431-011-1520-8

3. Baltimore RS, Gewitz M, Baddour LM et al. Infective Endocarditis in Childhood: 2015 Update. Circulation 2015;132(15):1487-515. DOI: 10.1161/CIR.0000000000000298

4. Johnson JA, Boyce TG, Cetta F et al. Infective Endocarditis in the Pediatric Patient: A 60-Year Single-Institution Review. Mayo Clinic Proceedings 2012;87(7):629-35. DOI: 10.1016/j.mayocp.2012.02.023

5. Бантьева М.Н., Маношкина Е.М., Соколовская Т.А., Матвеев Э.Н. Тенденции заболеваемости и динамика хронизации патологии у детей 0–14 лет в Российской Федерации. Социальные аспекты здоровья населения (сетевое издание). 2019;5(65):10. DOI: 10.21045/2071-5021-2019-65-5-10. Режим доступа: http://vestnik.mednet.ru/content/view/1105/30/lang.ru

Banteva M.N., Manoshkina E.M., Sokolovskaya T.A., Matveev E.N. Trends in incidence and dynamics of chronic pathology in children aged 0-14 in the Russian Federation. Social aspects of population health [serial online]. 2019;65(5):10. DOI: 10.21045/2071-5021-2019-65-5-10. Available at: http://vestnik.mednet.ru/content/view/1105/30/lang,ru/ (in Russian).

6. Деев И.А., Кобякова О.С.., Стародубов В.И. и др. Общая заболеваемость детского населения России (0–14 лет) в 2023 году: статистические материалы. М.: ФГБУ ЦНИИОИЗ Минздрава России, 2023. DOI: 10.21045/978-5-94116-164-5-2024

Deev I.A., Kobyakova O.S., Starodubov V.I. et al. The general morbidity of the Russian child population (0–14 years old) in 2023: statistical materials. Moscow: FSBI TSNIIOIZ, 2023. DOI: 10.21045/978-5-94116-164-5-2024 (in Russian).

7. Buergler H, Gregoriano C, Laager R et al. Microbiological Trends, In-hospital Outcomes, and Mortality in Infective Endocarditis: A Swiss Nationwide Cohort Study. Clin Infect Dis 2025;80(4):784-94. DOI: 10.1093/cid/ciae582.8

8. Delgado V, Marsan NA, de Waha S et al. 2023 ESC Guidelines for the management of endocarditis: Developed by the task force on the management of endocarditis of the European Society of Cardiology (ESC) Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS) and the European Association of Nuclear Medicine (EANM). Eur Heart J 2023;44(39):3948-4042. DOI: 10.1093/eurheartj/ehad193

9. Dias M, Amorim R, Correia AL et al. Hospitalizations for Infective Endocarditis in Children: 15-Year Analysis. Acta Médica Portuguesa 2025;38(6-7):377-84 DOI: 10.20344/amp.22196

10. Mulliken JS, Bainbridge ED. Infective Endocarditis. Medical Clinics of North America. 2025;109(3):667-81. DOI: 10.1016/j.mcna.2024.12.009

11. Fowler VG, Durack DT, Selton-Suty C et al. The 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis: Updating the Modified Duke Criteria. Clin Infect Dis 2023;77(4):518-26. DOI: 10.1093/cid/ciad271

12. Lau L, Baddour L, Hidalgo NF et al. Infective endocarditis: it takes a team. Eur Heart J 2025;46(24):2275-88. DOI: 10.1093/eurheartj/ehaf219

13. Лобзин Ю.В., Левина А.С. Клинические маски инфекционного эндокардита. Журнал инфектологии. 2015;7(2):14-20. DOI: 10.22625/2072-6732-2015-7-2-14-20

Lobzin Yu.V., Levina A.S. Clinical masks of infective endocarditis. Journal Infectology 2015;7(2):14-20. DOI: 10.22625/2072-6732-2015-7-2-14-20 (in Russian).

14. Na KW, Kim JS, Kim HJ. Infective Endocarditis Caused by Methicillin-Resistant Staphylococcus aureus Combined with Meningitis. Pediatric Infect Vaccine 2016;23(3):229-35. DOI: 10.14776/piv.2016.23.3.229

15. Lin YT, Hsieh KS, Chen YS et al. Infective endocarditis in children without underlying heart disease. J Microbiol Immunol Infection 2013;46(2):121-28. DOI: 10.1016/j.jmii.2012.05.001

16. Schuler SK, Crisinel PA, Joye R. Swiss Evaluation Registry for Pediatric Infective Endocarditis (SERPIE) – Risk factors for complications in children and adolescents with infective endocarditis. Int J Cardiol 2023;370(1):463-71. DOI: 10.1016/j.ijcard.2022.10.173

17. Abdulsalam TA, Khan F, Hussein H et al. A Rare Case of Pediatric Infective Endocarditis Initially Presenting as Meningitis in a Previously Healthy Child. Cureus 2025;17(7):e87712. DOI: 10.7759/cureus.87712

18. Eleyan L, Khan AA, Musollari G et al. Infective endocarditis in paediatric population. Eur J Pediatr 2021;180(10):3089-100. DOI: 10.1007/s00431-021-04062-7

19. Thom K, Hanslikd A, Russell JL et al. Incidence of infective endocarditis and its thromboembolic complications in a pediatric population over 30 years. Int J Cardiol 2018;252(2):74-9. DOI: 10.1016/j.ijcard.2017.10.085

For citation:Korovina O.A., Kantemirova M.G., Shamrin Yu.N., Musonda K., Bedin A.V., Novikova Yu.Yu., Ovsyannikov D.Yu., Abramyan M.A. Infective endocarditis of a native aortic valve of staphylococcal etiology in adolescents: a clinical case. Clinical review for general practice. 2026; 7 (5): 37–41 (In Russ.). DOI: 10.47407/kr2026.7.5.00837

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Clinical review for general practice