Abstract
Relevance. Adherence to treatment is a key condition for the control of arterial hypertension (AH). In real-world clinical practice, the frequency of irregular medication intake remains high, necessitating the study of predictors of low compliance to optimize outpatient care.
Aim. To comprehensively assess the level of adherence to antihypertensive therapy and identify factors associated with its reduction in outpatients.
Materials and methods. Adherence was assessed using the Morisky–Green scale (MMAS-8) in 225 patients with hypertension, stratified by age groups: 18–44 (n=20), 45–59 (n=70), 60–74 (n=97), and 75–89 years (n=38). Descriptive statistics, the χ² test, and binary logistic regression were used to identify predictors of low adherence (<6 points).
Results. Satisfactory adherence (≥6 points) was found in 21% (n=47) of patients, of whom 9% (n=20) demonstrated high adherence (8 points). Low adherence was recorded in 79% (n=178) of patients. Univariate analysis showed an association between low adherence and age ≥60 years (p=0.032). According to regression analysis, age ≥75 years remained an independent predictor (OR 3.1; 95% CI 1.2–8.0; p=0.018). Of all patients, 75% experienced difficulties in remembering to take medication (unintentional non-adherence), while 25% intentionally adjusted their therapy.
Conclusions. A high prevalence of reduced adherence was found among outpatients with hypertension, with a pronounced age association that was most significant in the elderly. The predominance of unintentional non-adherence highlights the need for implementing reminder technologies and optimizing pharmacotherapy.
Keywords: arterial hypertension, treatment adherence, treatment compliance, MMAS-8, outpatient practice, risk factors, personalized medicine, elderly patients.
For citation:Ayarapetov K.V., Ageeva A.A., Katkova A.V., Makarenkova E.M., Golovanova E.D. Compliance in patients with arterial hypertension and factors influencing adherence to antihypertensive therapy. Clinical review for general practice. 2026; 7 (6): 41–44 (In Russ.). DOI: 10.47407/kr2026.7.6.00861
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