Drugs affecting the outcomes and prognosis of dental treatment. Focus: proton pump inhibitors and implantology issues

Dmitry I. Trukhan , Anatoly F. Sulimov , Larissa Yu. Trukhan

For citation:

Abstract

In the interdisciplinary relationship between an internist and other specialists, the least studied aspects are their interactions with a dentist. Drug therapy for somatic diseases can impact a patient's dental status, as well as the results and prognosis of dental treatment. Proton pump inhibitors (PPIs) are the most effective medications for the treatment of acid-related diseases. Numerous studies have shown that long-term use of PPIs is associated with the development of osteoporosis and an increased risk of hip, spine, and wrist fractures. Implantology in dentistry involves the placement of artificial roots (implants) in the jawbone, followed by prosthetic restoration. We searched PubMed and Scopus databases up to January 5, 2026, for publications on the impact of PPIs on the results and prognosis of dental treatment. Experimental and clinical studies, reviews, and meta-analyses demonstrate a potential association between PPI use and implant failure and increased failure rates. To improve the effectiveness of dental treatment outcomes and prognosis, dentists need to be aware of the patient's concomitant/comorbid medical conditions and potential side effects of medications that may adversely affect oral organs and tissues.

Keywords: medications, proton pump inhibitors, bone tissue, implantology, implant, implant failure, implant rejection.

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For citation:Trukhan D.I., Sulimov A.F., Trukhan L.Yu. Drugs affecting the outcomes and prognosis of dental treatment. Focus: proton pump inhibitors and implantology issues. Clinical review for general practice. 2026; 7 (6): 94–98 (In Russ.). DOI: 10.47407/kr2026.7.6.00869

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Clinical review for general practice