Glycomics as a new vector in the study of chronic obstructive pulmonary disease pathogenesis

Oleg M. Uryasev , Maria A. Pristupa

For citation:

Abstract

Modern science is actively exploring a new field – glycomics, which deals with the study of glycation and glycoxidation processes in the human body. These studies help scientists discover new aspects in understanding the mechanisms of various diseases development. As glycomics evolves, more and more effective methods of treatment and prediction of many diseases are emerging. Particular attention is paid to the study of the interaction between various isoforms of the receptor for advanced glycation end products (RAGE) and their ligands. This is of great importance for understanding the course of respiratory diseases, particularly chronic obstructive pulmonary disease, and for developing new approaches to treating this disease.

Keywords: glycomics, glycation end product receptor, chronic obstructive pulmonary disease.

References

1. Thaysen-Andersen M, Kolarich D, Packer NH. Glycomics & glycoproteomics: from analytics to function. Mol Omics 2021;17(1):8-10.

2. Singh A. Glycoproteomics. Nat Methods 2021;18(1):28.

3. Rudd PM, Karlsson NG, Khoo KH et al. Glycomics and Glycoproteomics. Essentials of Glycobiology. Cold Spring Harbor Laboratory Press, Cold Spring Harbor (NY), 2022. P. 689–704.

4. Shen CY, Lu CH, Wu CH et al. The Development of Maillard Reaction, and Advanced Glycation End Product (AGE)-Receptor for AGE (RAGE) Signaling Inhibitors as Novel Therapeutic Strategies for Patients with AGE-Related Diseases. Molecules 2020;25(23):5591.

5. Елизаров М.А., Повереннова И.Е., Купаев В.И. и др. Особенности гликозилирования белков при рассеянном склерозе. Аспирантский вестник Поволжья. 2023;23(3):13-6.

Elizarov M.A., Povennova I.E., Kupaev V.I. and others. Features of protein glycosylation in multiple sclerosis. Postgraduate Bulletin The Volga region. 2023;23(3):13-6 (in Russian).

6. Dong H, Zhang Y, Huang Y, Deng H. Pathophysiology of RAGE in inflammatory diseases. Front Immunol 2022;13:931473.

7. Khalid M, Petroianu G, Adem A. Advanced Glycation End Products and Diabetes Mellitus: Mechanisms and Perspectives. Biomolecules 2022;12(4):542.

8. Khalid M, Alkaabi J, Khan MAB, Adem A. Insulin Signal Transduction Perturbations in Insulin Resistance. Int J Mol Sci 2021;22(16):8590.

9. Abedini A, Cao P, Plesner A et al. RAGE Binds Preamyloid IAPP Intermediates and Mediates Pancreatic β Cell Proteotoxicity. J Clin Invest 2018;128:682-98.

10. Haider SH, Oskuei A, Crowley G et al. Receptor for advanced glycation end-products and environmental exposure related obstructive airways disease: a systematic review. Eur Respir Rev 2019;28(151):180096.

11. Pouwels SD, Hesse L, Wu X et al. LL-37 and HMGB1 induce alveolar damage and reduce lung tissue regeneration via RAGE. Am J Physiol Lung Cell Mol Physiol 2021;321(4):L641-L652.

12. Zaigham S, Persson M, Jujic A et al. Measures of lung function and their relationship with advanced glycation end-products. ERJ Open Res 2020;6(2):00356-2019.

13. Lu T, Lahousse L, Wijnant S et al. The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study. Respir Res 2024;25(1):85.

14. Sharma A, Kaur S, Sarkar M et al. The AGE-RAGE Axis and RAGE Genetics in Chronic Obstructive Pulmonary Disease. Clin Rev Allergy Immunol 2021;60(2):244-58.

15. Шипунов И.Д., Купаев В.И., Жестков А.В. Бронхиальная астма с точки зрения гликомики. Российский аллергологический журнал. 2022;19(2):201-9.

Shipunov I.D., Kupaev V., Harshly A.V. Bronchial asthma from the point of view of glycomics. Russian Journal of Allergy. 2022;19(2):201-9 (in Russian).

16. Keefe J, Yao C, Hwang SJ et al. An Integrative Genomic Strategy Identifies sRAGE as a Causal and Protective Biomarker of Lung Function. Chest 2022;161(1):76-84.

17. Patregnani JT, Brooks BA, Chorvinsky E, Pillai DK. High BAL sRAGE is associated with low serum eosinophils and IgE in children with asthma. Children (Basel) 2020;7(9):110.

18. Marin-Oto M, Sanz-Rubio D, Santamaria-Martos F et al. Soluble RAGE in COPD, with or without coexisting obstructive sleep apnoea. Respir Res 2022;23(1):163.

19. Pratte KA, Curtis JL, Kechris K et al. Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD. Respir Res 2021;22(1):127.

20. Sin S, Lim MN, Kim J et al. Association between plasma sRAGE and emphysema according to the genotypes of AGER gene. BMC Pulm Med 2022;22(1):58.

21. Klont F, Horvatovich P, Bowler RP et al. Plasma sRAGE levels strongly associate with centrilobular emphysema assessed by HRCT scans. Respir Res 2022;23(1):15.

22. Chandanna Seri V, Kaleem Ullah M, Siddaiah JB et al. Reduced Serum sRAGE Levels Identify COPD and Reflect Disease Severity: Findings from a Cross-Sectional Study in India. Diagnostics (Basel) 2025;15(22):2910.

For citation:Uryasev O.M., Pristupa M.A. Glycomics as a new vector in the study of chronic obstructive pulmonary disease pathogenesis. Clinical review for general practice. 2026; 7 (6): 80–82 (In Russ.). DOI: 10.47407/kr2026.7.6.00867

All accepted articles publish licensed under a Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

Clinical review for general practice