Abstract
Myelin oligodendrocyte glycoprotein (MOG-IgG)-associated disease is a rare autoimmune inflammatory demyelinating disease of the central nervous system characterized by MOG antibody-mediated damage to the myelin sheath of neurons in the brain and spinal cord and the formation of various clinical phenotypes: from optic neuritis and transverse myelitis to acute disseminated encephalomyelitis and cortical encephalitis.
Although the clinical picture of this disease may seem like neuromyelitis optica spectrum disorder, most experts consider MOG-IgG-associated disease as a separate nosology with a characteristic pathogenesis. This article discusses the history of disease study, the basics of pathophysiology, the main clinical and radiological characteristics of the disease, as well as updated diagnostic criteria and modern treatment prospects. A clinical case of a patient with MOG-IgG-associated disease is presented.
Keywords: MOG-IgG-associated disease, neuromyelitis optica spectrum disorder, MOG antibodies.
For citation:Popova M.V., Bykova V.A., Ermolenko N.A., Tkachenko N.V., Shishkina V.V., Kolyadin D.A., Yudina M.A. MOG-IgG-associated disease: literature review and case report. Clinical review for general practice. 2026; 7 (6): 83–88 (In Russ.). DOI: 10.47407/kr2026.7.6.00868
All accepted articles publish licensed under a Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
