Abstract
Aim. To evaluate the influence of the Arg25Pro polymorphism of the TGFB1 gene on the clinical and laboratory parameters of ankylosing spondylitis (AS) and the formation of CVR in patients with AS.
Materials and methods. 176 patients with AS underwent genotyping for the Arg25Pro polymorphism of the SELE gene using allele-specific PCR; statistical analysis was performed using the Kruskal–Wallis test.
Results. Genotyping for the Arg25Pro polymorphism of the SELE gene was performed in 176 patients with AS using allele-specific PCR. Statistical analysis was performed using the Kruskal–Wallis test. The Arg/Pro phenotype was associated with higher values of BMI (p=0.012), creatinine (p=0.02), urea (p=0.031), uric acid (p<0.05), and the Arg-glucose variant (p=0.027). Arg/Arg homozygotes had a higher incidence of enthesitis (p=0.043) and eye lesions (p=0.024). Identification of the Arg/Pro genotype was associated with a higher incidence of stage 2 (p=0.05) and stage 2 (p=0.02) arterial hypertension (AH). Pyelonephritis was more often recorded with the Pro/Pro phenotype (p=0.05), gastrointestinal diseases – Arg/Arg (p=0.001).
Conclusion. The role of the Arg25Pro SNP of the TGFB1 gene in the development of extra-axial and extra-skeletal manifestations of AS, metabolic effects, and pathology of the kidneys and gastrointestinal tract has been demonstrated.
Keywords: ankylosing spondylitis, cardiovascular risk, comorbidity, TGFB1 gene, SNP Arg25Pro.
For citation:Gaffarova A.S., Beloglazov V.A., Yatskov I.A., Ageyeva E.S., Petrov A.V. The effect of the single nucleotide polymorphism Arg25Pro of TGFB1 gene on clinical and laboratory features and the formation of comorbid pathology associated with cardiovascular risk. Clinical review for general practice. 2026; 7 (6): 60–66 (In Russ.). DOI: 10.47407/kr2026.7.6.00864
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