Abstract
Chemoradiotherapy has been considered the standard treatment for advanced cancers of the cervix, uterus, vulva and vagina for more than 10 years. To date, there is insufficient information in the literature about late radiation complications in general and, in particular, about such severe ones as total vaginal necrosis, as well as about its consequences for patients.
Objective. To compare the clinical course and differential diagnosis of late total radiation necrosis and local recurrence of cancer of the female genital organs; based on the analysis of the results obtained, to determine the necessary and sufficient treatment methods.
Materials and methods. The article reflects the methods of comprehensive examination and differential diagnosis of late radiation total necrosis; reflects in detail the complex of therapeutic measures; provides data on dynamic monitoring of the results of complex treatment of 58 patients with radiation-induced (post-radiation) total necrosis of the genital tract, evaluates the results of complex treatment. The patients were treated in stages, taking into account the integrated approach and the presence of multiorgan pathology.
Conclusion. Conclusions are drawn about the need for an integrated approach in the diagnosis and treatment of late total radiation necrosis and the need to use this approach in clinical practice, since the final result of the complex treatment is the relief of debilitating complaints, lysis of non-viable tissues and complete scarring of soft tissue defects. This makes it possible to create conditions for tissue regeneration in places exposed to radiation, improve the quality of life and social adaptation of patients. Adverse factors that hinder the normal functioning of the connective tissue of the skin are reflected. In conclusion, the achieved results of the treatment are summarized; the timely use of complex treatment of late radiation necrosis is safe and effective.
Keywords: cancer of the female genital area, radiation complications, total radiation-induced necrosis, ionizing radiation, soft tissue defect, differential diagnosis, comprehensive treatment.
For citation:Chervyakova A.E., Ivanov S.A., Kaprin A.D. Late radiation-induced total necrosis the genital tract in women. Paradigms of etiology, pathogenesis, diagnosis and treatment. Clinical review for general practice. 2026; 7 (7): 39–48 (In Russ.). DOI: 10.47407/kr2026.7.7.00883
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