Clinical review for general practice

ISSN (Print) 2713-2552
ISSN (Online) 2782-5671
  • Home
  • about
  • archives
  • contacts
left
FULLSCREEN > Archive > 2025 > Vol 6, №1 (2025) > Surgical treatment of recurrent pelvic organ prolapse: what is important to know?

Surgical treatment of recurrent pelvic organ prolapse: what is important to know?

Mekan R. Orazov , Viktor E. Radzinsky , Farida F. Minnullina

For citation:


  • Abstract
  • About the Author
  • References

Abstract

High rate of recurrence after surgical correction remains the key problem of the pelvic organ prolapse (POP) treatment, while the key objective is the search for the ways to improve surgical techniques. Various surgical approaches, including minimally invasive, involving the use of mesh implants or native tissues have been developed, but neither patients, nor surgeons are satisfied with the results.
Aim: to analyze available scientific data on the efficacy and safety of surgical correction methods in terms of genital prolapse recurrence.
Methods. Analysis of scientific papers published in the ELibrary, PubMed, CochraneLibrary, Science Direct databases in 2010–2024 for the keywords “pelvic organ prolapse/пролапс тазовых органов”, “rectocele/ректоцеле”, “cystocele/цистоцеле”, “apical prolapse/апикальный пролапс”, “recurrence/рецидив”, “surgical treatment/оперативное лечение” was performed. 
Results. To date, no perfect surgical approach to treatment of POP has been developed; no optimal surgical procedures for correction of primary and recurrent POP allowing one to avoid the disease progression have been proposed. A comprehensive personalized approach based on thorough assessment of the pelvic floor condition taking into account all the existing risk factors of primary POP or new disease progression factors in case of recurrence is the key to reducing the POP recurrence rate. 
Conclusion. Verification of fascial defects during preoperative and intraoperative periods is believed to be critical for improvement of the POP surgical treatment outcomes. Sufficient extent of surgical intervention, elimination of all fascial defects, optimal use of MESH technologies might improve anatomical and subjective operative results, as well as reduce the risk of recurrence. The use of synthetic implants in a number of studies has proven to be effective, regardless of the ongoing discussions about safety of such methods. It is necessary to continue the research on a large sample, since it will make it possible to improve the long-term treatment outcomes. 
Keywords: pelvic organ prolapse, rectocele, cystocele, apical prolapse, recurrence, surgical treatment.

About the Author

Mekan R. Orazov 1 , Viktor E. Radzinsky 1 , Farida F. Minnullina 2

1 Patrice Lumumba Peoples' Friendship University of Russia (RUDN University), Moscow, Russia

2 Kazan Federal University, Kazan, Russia; Sadykov City Clinical Hospital No. 7, Kazan, Russia

References

1. Barber MD, Maher C. Epidemiology and outcome assessment of pelvic organ prolapse. Int Urogynecol J 2013;24(11):1783-90.
2. Kinman CL, Lemieux CA, Agrawal A et al. The relationship between age and pelvic organ prolapse bother. Int Urogynecol J 2017;28(5):751-5.
3. Schulten SFM, Claas-Quax MJ, Weemhoff M et al. Risk factors for primary pelvic organ prolapse and prolapse recurrence: an updated systematic review and meta-analysis. Am J Obstet Gynecol 2022;227(2):192-208.
4. Wu JM, Matthews CA, Conover MM et al. Lifetime risk of stress urinary incontinence or pelvic organ prolapse surgery. Obstet Gynecol 2014;123(6):1201-6.
5. Larouche M, Belzile E, Geoffrion R. Surgical management of symptomatic apical pelvic organ prolapse: a systematic review and meta-analysis. Obstet Gynecol 2021;137:1061-73.
6. American College of Obstetricians and Gynecologists, the American Urogynecologic Society. This Practice Bulletin is updated as highlighted to reflect the US Food and Drug Administration order to stop the sale of transvaginal synthetic mesh products for the repair of pelvic organ prolapse, Pelvic Organ Prolapse. Female Pelvic Med Reconstr Surg 2019;25:397-408.
7. Выпадение женских половых органов. Клинические рекомендации Минздрава России. М., 2024.
Prolapse of the female genital organs. Clinical recommendations of the Russian Ministry of Health. Moscow, 2024 (in Russian).
8. Zhou Q, Lu M, Li GS et al. Identification of potential molecular mechanisms and therapeutic targets for recurrent pelvic organ prolapse. Heliyon 2023;9(9):e19440.
9. Kurki A, Paakinaho K, Hannula M et al. Promoting cell proliferation and collagen production with ascorbic acid 2-phosphate-releasing poly(l-lactide-co-ε-caprolactone) membranes for treating pelvic organ prolapse. Regen Biomater 2024;11:rbae060.
10. Ismail S, Duckett J, Rizk D et al. Recurrent pelvic organ prolapse: International Urogynecological Association Research and Development Committee opinion. Int Urogynecol J 2016;27(11):1619-32.
11. Dietz HP, Mann KP. What is clinically relevant prolapse? An attempt at defining cutoffs for the clinical assessment of pelvic organ descent. Int Urogynecol J 2014;25(4):451-5.
12. Shek KL, Dietz HP. Assessment of pelvic organ prolapse: a review. Ultrasound Obstet Gynecol 2016;48(6):681-92.
13. Brennand EA, Scime NV, Huang B et al. Calgary Women’s Pelvic Health Research Group. Hysterectomy versus Uterine Preservation for Pelvic organ prolapse Surgery (HUPPS): A prospective cohort study. Am J Obstet Gynecol 2024 Oct 18:S0002-9378(24)01079-2.
14. Van Oudheusden AMJ, Weemhoff M, Menge LF, Essers BAB. Gynecologists' perspectives on surgical treatment for apical prolapse: a qualitative study. Int Urogynecol J 2023;34(11):2705-12.
15. Toh VV, Bogne V, Bako A. Management of recurrent vault prolapse. Int Urogynecol J 2012;23(1):29-34.
16. Martins SB, Castro RA, Takano CC et al. Efficacy of Sacrospinous Fixation or Uterosacral Ligament Suspension for Pelvic Organ Prolapse in Stages III and IV: Randomized Clinical Trial. Rev Bras Ginecol Obstet 2023;45(10):e584-e593.
17. Payebto Zoua E, Boulvain M, Dällenbach P. The distribution of pelvic organ support defects in women undergoing pelvic organ prolapse surgery and compartment specific risk factors. Int Urogynecol J 2022;33(2):405-9.
18. Haya N, Baessler K, Christmann-Schmid C et al. Prolapse and continence surgery in countries of the Organization for Economic Cooperation and Development in 2012. Am J Obstet Gynecol 2015;212(6):755.e1-755.e27.
19. Maher C, Feiner B, Baessler K et al. Surgery for Women with Anterior Compartment Prolapse. Cochrane Database Syst Rev 2016;11:CD004014.
20. Slade E, Daly C, Mavranezouli I et al. Primary Surgical Management of Anterior Pelvic Organ Prolapse: A Systematic Review, Network Meta-Analysis and Cost-Effectiveness Analysis. BJOG 2020;127:18-26.
21. Weemhoff M, Vergeldt TF, Notten K et al. Avulsion of puborectalis muscle and other risk factors for cystocele recurrence: a 2-year follow-up study. Int Urogynecol J 2012;23(1):65-71.
22. Moen M, Noone M, Vassallo B. Anterior colporrhaphy: why surgeon performance is paramount. Int Urogynecol J 2014;25(7):857-62.
23. Graefe F, Schwab F, Tunn R. Double-layered anterior colporrhaphy (DAC)-video and mid-term follow-up of 60 patients. Int Urogynecol J 2023;34(1):297-300.
24. Eilber KS, Alperin M, Khan A et al. Outcomes of vaginal prolapse surgery among female Medicare beneficiaries: the role of apical support. Obstet Gynecol 2013;122(5):981-7.
25. Hu Q, Huang S, Yang X et al. Long-term outcomes of cable-suspended suture technique versus conventional suture for anterior vaginal wall prolapse: a retrospective cohort study. BMC Womens Health 2023;23(1):72.
26. Tsui WL, Ding DC. Anterior Colporrhaphy and Paravaginal Repair for Anterior Compartment Prolapse: A Review. Medicina (Kaunas) 2024;60(11):1865.
27. Ko KJ, Lee K-S. Current Surgical Management of Pelvic Organ Prolapse: Strategies for the Improvement of Surgical Outcomes. Investig Clin Urol 2019;60:413-24.
28. Karram M, Maher C. Surgery for posterior vaginal wall prolapse. Int Urogynecol J 2013;24(11):1835-41.
29. Balata M, Elgendy H, Emile SH et al. Functional Outcome and Sexual-Related Quality of Life After Transperineal Versus Transvaginal Repair of Anterior Rectocele: A Randomized Clinical Trial. Dis Colon Rectum 2020;63(4):527-37.
30. Farid M, Madbouly KM, Hussein A et al. Randomized controlled trial between perineal and anal repairs of rectocele in obstructed defecation. World J Surg 2010;34:822-9.
31. Marino G, Frigerio M, Barba M et al. Native Tissue Posterior Compartment Repair for Isolated Posterior Vaginal Prolapse: Anatomical and Functional Outcomes. Medicina (Kaunas) 2022;58(9):1152.
32. Luo J, Chen L, Fenner DE et al. A multi-compartment 3-D finite element model of rectocele and its interaction with cystocele. J Biomech 2015;48(9):1580-6.
33. Liao YH, Ng SC, Chen GD. Correlation of severity of pelvic organ prolapse with lower urinary tract symptoms. Taiwan J Obstet Gynecol 2021;60(1):90-4.
34. Lewicky-Gaupp C, Yousuf A, Larson KA et al. Structural position of the posterior vagina and pelvic floor in women with and without posterior vaginal prolapse. Am J Obstet Gynecol 2010;202(5):497.e1-6.
35. Malik RD, Christie AL, Zimmern PE. Posterior Compartment Prolapse Occurrence After Anterior Vaginal Wall Suspension. Urology 2019;133:84-90.
36. Yin Y, Xia Y, Ji S et al. Modified laparoscopic sacrocolpopexy for advanced posterior vaginal wall prolapse: a 3-year prospective study. Ginekol Pol 2024 Oct 29.
37. Sarlos D, Kots L, Ryu G, Schaer G. Long-term follow-up of laparoscopic sacrocolpopexy. Int Urogynecol J 2014;25(9):1207-12.
38. Dallas K, Elliott CS, Syan R et al. Association Between Concomitant Hysterectomy and Repeat Surgery for Pelvic Organ Prolapse Repair in a Cohort of Nearly 100,000 Women. Obstet Gynecol 2018;132(6):1328-36.
39. Forsgren C, Lundholm C, Johansson AL et al. Vaginal hysterectomy and risk of pelvic organ prolapse and stress urinary incontinence surgery. Int Urogynecol J 2012;23(1):43-8.
40. Lykke R, Blaakær J, Ottesen B, Gimbel H. The indication for hysterectomy as a risk factor for subsequent pelvic organ prolapse repair. Int Urogynecol J 2015;26(11):1661-5.
41. Husby KR, Gradel KO, Klarskov N. Pelvic organ prolapse following hysterectomy on benign indication: a nationwide, nulliparous cohort study. Am J Obstet Gynecol 2022;226(3):386.e1-386.e9.
42. Mairesse S, Chazard E, Giraudet G et al. Complications and reoperation after pelvic organ prolapse, impact of hysterectomy, surgical approach and surgeon experience. Int Urogynecol J 2020;31(9):1755-61.
43. Kuittinen T, Mentula M, Tulokas S et al. Recurrent pelvic organ prolapse after hysterectomy; a 10-year national follow-up study. Arch Gynecol Obstet 2024;310(5):2705-15.
44. Liang L, Ao S, Wang S et al. Efficacy and safety of Le Fort colpocleisis in the treatment of stage III-IV pelvic organ prolapse. BMC Womens Health 2024;24(1):618.
45. Maher C, Feiner B, Baessler K, Schmid C. Surgical management of pelvic organ prolapse in women. Cochrane Database Syst Rev 2013;(4):CD004014.
46. Da Silveira SDRB, Auge AP, Jarmy-Dibella ZI et al. A multicenter, randomized trial comparing pelvic organ prolapse surgical treatment with native tissue and synthetic mesh: A 5-year follow-up study. Neurourol Urodyn 2020;39(3):1002-11.
47. Food and Drug Administration (2011) FDA safety communication: UPDATE on serious complications associated with transvaginal placement of surgical mesh for pelvic organ prolapse. Silver Spring (MD): FDA. Available at: http://www.fda.gov/ MedicalDevices/Safety/AlertsandNotices/ucm262435.htm. Accessed: 07.01.2012.

For citation:Orazov M.R., Radzinsky V.E., Minnullina F.F. Surgical treatment of recurrent pelvic organ prolapse: what is important to know? Clinical review for general practice. 2025; 6 (2): 106–112 (In Russ.). DOI: 10.47407/kr2024.6.1.00558


All accepted articles publish licensed under a Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

  • About
  • Editorial board
  • Ethics
  • For authors
  • Author fees
  • Peer review
  • Contacts

oa
crossref
анри


  Indexing

doaj
elibrary

Address of the Editorial Office:

127055, Moscow, s/m 37

Correspondence address:

115054, Moscow, Zhukov passage, 19, fl. 2, room XI


Managing Editor:

+7 (495) 926-29-83

id@con-med.ru