Аннотация
В 1984 г. датские дерматологи описали кожные высыпания, ограниченные ягодицами с возможным вовлечением интертригинозных зон и сгибательных областей, и назвали этот паттерн «синдром бабуина». В начале ХХI в. швейцарскими дерматологами была предложена новая аббревиатура SDRIFE (симметричная интертригинальная и изгибная экзантема, связанная с лекарственными средствами) вместе с пятью характерными диагностическими критериями. Мы провели поиск в базе данных PubMed по ключевым терминам: «baboon syndrome», «symmetrical drug-related intertriginous and flexural exanthema», «SDRIFE» с момента первой публикации (1984 г.) по 30.04.2023. Найдено 120 описаний синдрома бабуина или SDRIFE, который несколько чаще встречался у мужчин. Отмечено увеличение частоты развития с возрастом, 60% случаев приходилось на пациентов старше 50 лет. Географически более половины (52,4%) случаев зарегистрированы в Европе, преимущественно в южноевропейских и западноевропейских странах, 20% – в Индии и 16,2% – в азиатских странах. Обращает на себя внимание многообразие лекарственных препаратов, которые могут быть причиной развития синдрома бабуина/SDRIFE. Почти половина – 59 (49,2%) случаев из 120 представленных в обзоре, связаны с антибиотиками, 24 (20%) случая – с антибиотиками группы пенициллина. В период пандемии новой коронавирусной инфекции были описаны случаи развития SDRIFE у больных COVID-19 и после вакцинации от COVID-19. Ведущее место в диагностике и лечении SDRIFE принадлежит дерматологу. Однако с учетом многообразия препаратов-виновников с SDRIFE может столкнуться в своей практике врач любой специальности.
Ключевые слова: синдром бабуина, симметричная интертригинальная и изгибная экзантема, связанная с лекарственными средствами, синдром SDRIFE, лекарственные препараты, препараты-виновники, эпидемиология
Об авторе
Д.И. Трухан
ФГБОУ ВО «Омский государственный медицинский университет» Минздрава России, Омск, Россия
dmitry_trukhan@mail.ru
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Для цитирования:Трухан Д.И. Синдром бабуина или симметричная интертригинальная и изгибная экзантема, связанная с лекарственными средствами. Обзор клинических случаев. Клинический разбор в общей медицине. 2023; 4 (5): 63–70. DOI: 10.47407/kr2023.4.5.00236
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