«Железный занавес» антиэйджинга: что за ним скрывается?

Для цитирования:

Аннотация

Железодефицитные состояния в настоящее время являются одной из наиболее актуальных и нерешенных проблем антивозрастной медицины. Пациентки старшего репродуктивного и пери-/постменопаузального возраста представляют собой наиболее «уязвимые когорты» для реализации дефицита железа. В настоящее время доказаны как краткосрочные, так и долговременные последствия ферродефицита, ассоциированные с неблагоприятными последствиями для здоровья и качества жизни. В обзоре рассмотрены ключевые детерминанты развития железодефицита у пациенток старшего репродуктивного, пери- и постменопаузального возраста и их клинический менеджмент на основе отечественных и международных рекомендаций.
Ключевые слова: железодефицитная анемия, латентный дефицит железа, ферритин, протеин сукцинилат железа (III).

Список литературы

1. Ageing and Health. World Health Organization. 2021. URL: https:// www.who.int/news-room/fact-sheets/detail/ageing-and-health

2. Улумбекова Г.Э., Прохоренко Н.Ф., Гиноян А.Б., Калашникова А.В. Системный подход к достижению общенациональной цели по увеличению ожидаемой продолжительности жизни до 78 лет к 2024 году. Экономика. Налоги. Право. 2019;12(2):19-30.

Ulumbekova G.E., Prokhorenko N.F., Ginoyan A.B., Kalashnikova A.V. A systematic approach to achieving the national goal of increasing life expectancy to 78 years by 2024. Economy. Taxes. Right. 2019;12(2):19-30 (in Russian).

3. Turawa E, Awotiwon O, Dhansay MA et al. Prevalence of Anaemia, Iron Deficiency, and Iron Deficiency Anaemia in Women of Reproductive Age and Children under 5 Years of Age in South Africa (1997–2021):

A Systematic Review. Int J Environ Res Public Health 2021;18:

12799.

4. WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations, 2020. URL: https://www.jstor.org/ stable/resrep33067.2

5. Pasricha SR, Tye-Din J, Muckenthaler MU, Swinkels DW. Iron deficiency. Lancet 2021;397:233-48.

6. Hassan N, Schapkaitz E, Rhemtula H, Ncete N. Incidence and Impact on Quality of Life of Heavy Menstrual Bleeding in Women on Oral Anticoagulant Therapy. Clinical and Applied Thrombosis/Hemostasis 2024;30:10760296241281366.

7. Mast AE, Szabo A, Stone M et al. The benefits of iron supplementation following blood donation vary with baseline iron status. Am J Hematol 2020;95:784-91.

8. Percy L, Mansour D, Fraser I. Iron deficiency and iron deficiency anaemia in women. Best Pract Res Clin Obstet Gynaecol 2017; 40: 55-67.

9. Friedman AJ, Chen Z, Ford P et al. Iron deficiency anemia in women across the life span. J Womens Health (Larchmt) 2012;21:1282-9.

10. Iron. Fact Sheet for Health Professionals. National Institutes of Health. Updated April 2022. Accessed February 12, 2023.

11. Molino CDGRC, Woll L, Wieczorek M et al; DO-HEALTH Research Group. Association between iron deficiency and hospitalization rate in community-dwelling older adults: A 3-year prospective observational study of DO-HEALTH. The American Journal of Clinical Nutrition 2023;117(1):12-21.

12. Korkmaz U, Korkmaz N, Yazici S et al. Anemia as a risk factor for low bone mineral density in postmenopausal Turkish women. Eur J Intern Med 2012;23:154-58.

13. Harris MM, Houtkooper LB, Stanford VA et al. Dietary iron is associated with bone mineral density in healthy postmenopausal women.

J Nutr 2003;133:3598-602.

14. Onal ED, Usluogulları A. Anemia and osteoporosis: Causal association or epiphenomenon? Eur J Intern Med 2012;23:e117

15. Yang J, Li Q, Feng Y, Zeng Y. Iron deficiency and iron deficiency anemia: Potential risk factors in bone loss. International Journal of Molecular Sciences 2023;24(8):6891.

16. Wright I, Blanco-Rojo R, Fernandez MC et al. Bone remodelling is reduced by recovery from iron-deficiency anaemia in premenopausal women. J Physiol Biochem 2013;69:889-96.

17. Toxqui L, Vaquero MP. Chronic iron deficiency as an emerging

risk factor for osteoporosis: A hypothesis. Nutrients 2015;7:2324-44.

18. Toxqui L, Perez-Granados AM, Blanco-Rojo R et al. Low iron status as a factor of increased bone resorption and effects of an iron and vitamin D-fortified skimmed milk on bone remodelling in young Spanish women. Eur J Nutr 2014;53:441-8.

19. Masini G, Graham FJ, Pellicori P et al. Criteria for iron deficiency in patients with heart failure. J Am Coll Cardiol 2022;79:341-51.

20. GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet (London) 2017;390:1211-59.

21. Fitzsimons S, Yeo TJ, Ling LH et al. Impact of change in iron status over time on clinical outcomes in heart failure according to ejection fraction phenotype. ESC Heart Fail 2021;8:4572-83.

22. Graham FJ, Friday JM, Pellicori P et al. Assessment of haemoglobin and serum markers of iron deficiency in people with cardiovascular disease. Heart 2023;109(17):1294-301.

23. Felek D. Evaluation of cognitive functions of patients with anemia. Cumhuriyet Medical Journal 2023;45(1):62-5.

24. Железодефицитная анемия. Федеральные клинические рекомендации. М., 2021.

Iron deficiency anemia. Federal clinical guidelines. Moscow, 2021 (in Russian).

25. James L Harper, Emmanuel C Besa. Iron Deficiency Anemia Workup. Medscape. 2023. URL: https://emedicine.medscape.com/article/202333-workup#c9

26. Sonoda K. Iron deficiency anemia: guidelines from the American Gastroenterological Association. American Family Physician 2021;104(2):211-2.

27. Romano AD et al. Molecular aspects and treatment of iron deficiency in the elderly. International Journal of Molecular Sciences 2020;21(11):3821.

28. Fougère B et al. Prevalence of iron deficiency in patients admitted to a geriatric unit: a multicenter cross-sectional study. BMC geriatrics 2024;24(1):112.

29. Portugal-Nunes C et al. Iron status is associated with mood, cognition, and functional ability in older adults: A cross-sectional study. Nutrients 2020;12(11):3594.

30. The Global Prevalence of Anaemia in 2011. WHO. 2015. URL: https://www.who.int/publications/i/item/9789241564960

31. Белоконова Н.А. и др. Исследование физико-химических свойств препаратов протеин сукцинилат железа (III) и гидроксид полимальтозат железа (III). Вестник Томского государственного университета, 2024.

Belokonova N.A. et al. Investigation of the physico-chemical properties of the preparations protein iron (III) succinylate and iron (III) polymaltosate hydroxide. Bulletin of Tomsk State University, 2024 (in Russian).

32. Martinez Frances A, Leal Martinez-Bujanda J. Efficacy and tolerability of oral iron protein succinylate: a systematic review of three decades of research. Current Medical Research and Opinion 2020;36(4):613-23.

33. Urso K, Leal Martínez-Bujanda J, Del Prado J. M. Iron protein succinylate in the management of iron deficiency anemia: A comparative study with ferrous sulphate at low and high therapeutic doses. Nutrients 2021;13(3):968.

34. AGA Clinical Practice Update on Management of Iron Deficiency Anemia: Expert Review. DeLoughery, Thomas G et al. Clinical Gastroenterology and Hepatology 2015;22(8):1575-83.

35. McDonald EM, Mousa S, Ram FS. Iron supplementation for iron-deficiency anaemia. Journal of Prescribing Practice 2023;5(3):118-21.

36. Garzon S, Cacciato PM, Certelli C et al. Iron deficiency anemia in pregnancy: Novel approaches for an old problem. Oman Medical Journal 2020;35(5):e166.

Для цитирования:Оразов М.Р., Радзинский В.Е., Долгов Е.Д. «Железный занавес» антиэйджинга: что за ним скрывается? Клинический разбор в общей медицине. 2024; 5 (9): 43–49. DOI: 10.47407/kr2024.5.9.00477

Журнал предоставляет свободный доступ с возможностью использовать статьи в некоммерческих целях при условии указания авторства в рамках лицензии CC BY-NC-SA 4.0 (https://creativecommons.org/licenses/by-nc-sa/4.0/deed.ru)

Клинический разбор в общей медицине